Evidence map›Paper›PMID 41712642›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Plastid 2-oxoglutarate-dependent dioxygenases mediate stereoselective C14β-hydroxylation in cardenolide biosynthesis.

Jianhua Wang, Xuan Zhou, Wenjuan Ji, Jianghu Bian, Changjian Zhang, Hong Zhou, Changheng Shan, Ning An, Rongchi Li, Quanzhe Li and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jianhua Wang *Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-2894-1040
Xuan Zhou *Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Wenjuan Ji *Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Jianghu BianShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Changjian ZhangShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Hong ZhouShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Changheng ShanShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0009-0006-6562-2849
Ning AnShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Rongchi LiShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.
Quanzhe LiSchool of Pharmaceutical Sciences, Shanghai Key Laboratory of Chiral Drugs and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Si-Hua HouSchool of Pharmaceutical Sciences, Shanghai Key Laboratory of Chiral Drugs and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Zhenhua LiuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0002-1786-883X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardenolides, widely distributed across multiple plant families, have long been utilized in traditional and modern medicine for treating heart failure and various cancers. Despite progress in understanding the initial steps of cardenolide biosynthesis, the evolutionary mechanisms behind the production of structurally diverse cardenolides across plant families remain poorly understood. Here, we report the genome sequence of

Indexed as

CardenolidesKetoglutaric AcidsMixed Function OxygenasesPlant ProteinsPlastidsApocynaceaeCytochrome P-450 Enzyme SystemHydroxylationPhylogenyStereoisomerismCardenolidesCytochrome P-450 Enzyme SystemKetoglutaric AcidsMixed Function OxygenasesPlant Proteins2-oxoglutarate-dependent dioxygenasescardenolidesindependent evolutionstereo-inverted hydroxylationsteroid C14-functionalization

Identifiers

PMID41712642
PMCPMC12933105

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.