Evidence map›Paper›PMID 41712562›Full record

ArticlePLoS neglected tropical diseases2026

Synergistic effects of multifactor interactions on the transmission of Echinococcus spp. on the Qinghai-Tibet Plateau.

Ao Chen, Zhi Li, Ru Meng, Hongrun Ge, Xueyong Zhang, Hong Duo, Yuting Zhao, Zhihong Guo, Xiuying Shen, Rui Zhou and 1 more

Abstract read
In one paragraph

Article in PLoS neglected tropical diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ao ChenAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Zhi LiAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Ru MengXining Animal Disease Control Center, Xining, China.
Hongrun GeAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Xueyong ZhangAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Hong DuoAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Yuting ZhaoAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Zhihong GuoAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Xiuying ShenAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Rui ZhouAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.
Yong FuAcademy of Animal Science and Veterinary, Qinghai Provincial Key Laboratory of Pathogen Diagnosis for Animal Diseases and Green Technical Research for Prevention and Control, College of Agriculture and Husbandry, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Qinghai University, Xining, China.ORCID https://orcid.org/0000-0003-3354-9107

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severe endemicity of Echinococcus spp. on the Qinghai‒Tibet Plateau (QTP) necessitates the identification of key risk factors influencing its transmission and distribution in northeastern QTP sylvatic cycles, alongside multifactorial interactions within the "environment-host-parasite" system. Field monitoring, multi source remote sensing data, and geographic detector techniques were integrated to elucidate the coupling relationships between the distribution and dissemination of Echinococcus spp. and geographical environmental factors. Land surface temperature (LST) was identified as a critical risk factor, exhibiting a significant negative correlation with Echinococcus spp. distribution (P < 0.01), while the interactive effects between factors surpassed individual impacts. The highest potential infection risk was localized in areas overlapping the northeastern plateau and the Three-River-Source core region, characterized by pronounced temperature fluctuations, low humidity, and intense radiation. On the basis of these findings, an ecoepidemiological hypothesis is proposed: the unique QTP habitat facilitates the evolution of a multi host parasitic system in Echinococcus spp.; subsequent host-mediated environmental modifications optimize dispersal conditions, jointly amplifying Echinococcus spp. transmission; and the synergistic coupling of "environmental-host-pathogen" dynamics underpins Echinococcus spp. endemicity on the QTP. This study provides a technical foundation for early risk warning and targeted control strategies for natural Echinococcus spp. foci.

Indexed as

EchinococcosisEchinococcusAnimalsEcosystemHost-Parasite InteractionsHumansRisk FactorsTemperatureTibet

Identifiers

PMID41712562
PMCPMC12919829

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.