ArticleACS chemical neuroscience2026
Imidazole as a Pendant Reactivation Ligand Increases Efficacy Scope for Reactivation and Resurrection of Organophosphorus-Inhibited/Aged Cholinesterases by Quinone Methide Precursors.
Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Organophosphorus (OP) inhibition of acetylcholinesterase (AChE) continues to pose a deadly risk to human health. Despite decades of research on oximes, improved therapeutics are still needed as most oximes fail to cross the blood-brain barrier, none exhibit efficacy against the OP-aged form of AChE, and reactivation by oximes results in a toxic byproduct. However, despite efforts to replace oxime therapeutics, many of the new candidates fall short in broad-scope activity or sufficient efficacy relative to the oxime therapeutics. Previously, researchers have used imidazole or Mannich phenol moieties as a basic therapeutic handle for reactivation of OP-inhibited forms of AChE. Herein, we report a novel strategy of utilizing Mannich phenol quinone methide precursors (QMPs), which are capable of reactivation and resurrection of OP-inhibited and OP-aged AChE, linked to a pendant
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