ArticleMagma (New York, N.Y.)2026
Detection of regional metabolic alteration using 7T deuterium metabolic imaging in MRI-negative,
Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
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Abstract
objectiveIdentifying presumed epileptogenic region (PER) in MRI-negative epilepsy patients is crucial for successful surgical outcomes. This study aims to determine whether dynamic deuterium metabolic imaging (DMI) at 7Tesla can detect region-specific metabolic alterations in MRI-negative,
methodsFive drug-resistant MRI-negative,
resultsPlasma glucose and
conclusionsUltra-high-field DMI revealed elevated hippocampal glutamatergic turnover in MRI negative epilepsy patients, with the highest levels in the epileptogenic hippocampus. These findings indicate the presence of subtle metabolic alterations in hippocampal tissue, supporting the potential of DMI to capture pathophysiological changes that remain invisible to conventional imaging.
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