Evidence map›Paper›PMID 41712074›Full record

ArticleMolecular diversity2026

Fluopyram analogues containing a five-membered heterocyclic ring moiety: synthesis, nematicidal activity and molecular docking study.

Zhitian Huang, Shenghong Jing, Qianyu Huang, Jie Chu, Hao Ling, Jiayi Wang, Gonghua Song

Abstract read
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Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zhitian HuangShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China.
Shenghong JingShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China.
Qianyu HuangShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China.
Jie ChuShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China.
Hao LingShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China.
Jiayi WangShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China.
Gonghua SongShanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai, People's Republic Of China. ghsong@ecust.edu.cn.

Funding

Shanghai Municipal Commission of Science and Technology Grant No. YDZX20253100001003
6 · The paper itself

Abstract

Plant-parasitic nematode (PPNs) infections threaten global crop protection and result in substantial annual losses to agriculture worldwide. However, only a limited number of nematicides are currently available, and drug resistance is becoming a more significant concern. Therefore, there is an urgent need to develop new, highly effective, and environmentally friendly nematicides. This study designed and synthesized forty-two novel fluopyram analogues containing five-membered heterocyclic molecules via a "Ring Replacement" strategy. Results from the nematicidal activity testing showed that all the target compounds showed certain activity against Caenorhabditis elegans. Notably, compound 21r demonstrated an LC

Indexed as

Antinematodal AgentsHeterocyclic CompoundsMolecular Docking SimulationPyridinesAnimalsBenzamidesCaenorhabditis elegansStructure-Activity RelationshipAntinematodal AgentsBenzamidesHeterocyclic CompoundsN-(2-(3-chloro-5-(trifluoromethyl)-2-pyridyl)ethyl)-alpha,alpha,alpha-trifluoro-o-toluamidePyridinesCaenorhabditis elegansFive-membered heterocyclic ringMolecular dockingNematicidal activity

Identifiers

PMID41712074

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.