Evidence map›Paper›PMID 41711976›Full record

ArticleArchives of virology2026

Construction of recombinant OPIV3 virus vectoring bivalent Mycoplasma ovipneumoniae adhesins.

Xu Zhang, Yijia Liu, Boxuan Yin, Changyan Li, Miao Sun, Qinghong Xue, Jinhai Huang

Abstract read
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In one paragraph

Article in Archives of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xu Zhang *School of Life Sciences, Tianjin University, Tianjin, 300072, China.
Yijia Liu *School of Life Sciences, Tianjin University, Tianjin, 300072, China.
Boxuan YinSchool of Life Sciences, Tianjin University, Tianjin, 300072, China.
Changyan LiSchool of Life Sciences, Tianjin University, Tianjin, 300072, China.
Miao SunChina Institute of Veterinary Drug Inspection, Beijing, 100081, China.
Qinghong XueChina Institute of Veterinary Drug Inspection, Beijing, 100081, China. 732574709@qq.com.ORCID http://orcid.org/0000-0002-9557-6680
Jinhai HuangSchool of Life Sciences, Tianjin University, Tianjin, 300072, China. jinhaih@tju.edu.cn.ORCID http://orcid.org/0000-0002-1073-533X

Funding

Jingjinji collaborative rearch pragram S25ZX27034.the key Tianjin Science and Technology Support Project in China 24YFZCSN00180
6 · The paper itself

Abstract

Mycoplasma ovipneumoniae (MO) and Ovine parainfluenza virus type 3 (OPIV3) are significant pathogens implicated in ovine respiratory diseases, which impose substantial threats to extensive sheep farming. However, no commercial bivalent vaccines targeting both pathogens are currently available. In this study, we constructed a recombinant live-attenuated OPIV3 using Red/ET recombination, inserting MO adhesion protein genes (P60, P113) between the N and P genes of the OPIV3 genome. The recombinant candidate rOPIV3-MO was successfully generated and inhibited growth kinetics similar to those of the parental OPIV3 TJ2022 strain. Immunization trials in sheep indicated that rOPIV3-MO displayed a favorable safety profile. Both rOPIV3-MO and OPIV3 TJ2022 inoculation induced specific and neutralizing antibodies, as well as T-cell receptor (TCR) rearrangements.

Indexed as

Adhesins, BacterialBacterial VaccinesMycoplasma ovipneumoniaePneumonia, MycoplasmaRespirovirus InfectionsSheep DiseasesAnimalsAntibodies, BacterialAntibodies, NeutralizingAntibodies, ViralGenetic VectorsSheepVaccines, AttenuatedVaccines, SyntheticAdhesins, BacterialAntibodies, BacterialAntibodies, NeutralizingAntibodies, ViralBacterial VaccinesVaccines, AttenuatedVaccines, SyntheticAdhesionMycoplasma ovipneumoniaeOvine parainfluenza virus type 3Viral-vectored Vaccines

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.