ArticleJournal of gastroenterology2026
Targeting the ZDHHC9-mediated STAT1 palmitoylation-phosphorylation conversion inhibits gastric cancer progression.
Article in Journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Single-Cell Transcriptomic Analysis Identifies an OLFM4-Associated Gastric Cancer Cell State with Palmitoylation-Related Signatures and Altered Metabolic Activities.Biomolecules · 2026Article
- The emerging role of ZDHHC9 in cancer: from protein palmitoylation to tumor progression and immune regulation.Frontiers in immunology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundPalmitoyl transferases ZDHHCs and its mediated protein palmitoylation in several malignant tumors have been reported. However, the role in gastric cancer (GC) has not yet been fully elucidated.
methodsVarious experimental techniques were employed to investigate the role of ZDHHCs and related protein palmitoylation in GC, mainly including acyl-biotinyl exchange assay, co-immunoprecipitation, immunohistochemistry, western blot, immunofluorescence, and confocal imaging.
resultsWe identified widespread protein palmitoylation in GC, and the palmitoylation inhibitor 2-bromopalmitate was found to inhibit progression of GC in vitro. Screening of differentially expressed ZDHHCs revealed that abnormal overexpression of ZDHHC9 was associated with poor prognosis in GC patients. Silencing ZDHHC9 inhibited GC growth and induced apoptosis. Further, ZDHHC9 palmitoylated STAT1 at Cys577. More specifically, ZDHHC9 mediated STAT1 conversion of Cys577 S-palmitoylation and Tyr701 phosphorylation via the JAK1-STAT1 signaling pathway. Notably, palmitoylation of STAT1 at Cys577 is a key mediator of ZDHHC9-mediated GC progression, relying on nuclear pSTAT1-Tyr701 and its transcription of downstream genes.
conclusionsTaken together, ZDHHC9 promotes GC progression by regulating the conversion of STAT1 S-palmitoylation and phosphorylation, providing potential therapeutic targets for GC treatment.
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Registered trials
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