ReviewJournal of bone and mineral metabolism2026
Skeletal stem cell lineages in osteosarcoma and bone metastasis.
Review in Journal of bone and mineral metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Osteocytes in the Metastatic Bone Niche: Mechanistic Pathways and Therapeutic Targets.Pharmaceuticals (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
introductionSkeletal stem cells (SSCs) and their lineage derivatives play essential roles in bone development, maintenance, and regeneration. In addition to their physiological functions, SSCs have been implicated in primary bone tumor development and bone metastasis. Recent lineage-tracing studies have identified fibroblast growth factor receptor 3 (Fgfr3)-positive endosteal stem cells as a distinct SSC population residing along the endosteal surface of juvenile long bones.
methodsThis review comprehensively synthesizes previous studies on skeletal stem cells and their lineage derivatives, integrating findings from lineage-tracing approaches, genetically engineered mouse models, and bone tumor models. By organizing current knowledge of SSC hierarchy and differentiation, we provide a framework for understanding how SSC-derived lineages contribute to both bone homeostasis and cancer-related processes.
resultsFgfr3
conclusionCollectively, these findings highlight Fgfr3
Indexed as
Identifiers
41711876What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.