ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Improvement of functional mitral and tricuspid regurgitation in patients with atrial fibrillation after sinus rhythm restoration-the Berlin FMTR registry.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFunctional mitral and tricuspid regurgitation (MR and TR) are caused by changes in atrial and/or ventricular geometry. Atrial fibrillation (AF) has been identified as a cause of functional MR and TR, but the arrhythmia may also occur as a consequence of the valvular dysfunction. Data on the success of restoring sinus rhythm (SR) and subsequent MR/TR improvement remain limited. This study reports findings from the prospective Berlin-FMTR registry, which included patients with AF and newly diagnosed moderate or worse functional MR or TR undergoing cardioversion or ablation. METHODS AND
resultsEighty patients (46% male, median age 73.7 years) with persistent AF and at least moderate MR or TR underwent rhythm control via cardioversion or catheter ablation. Follow-up assessments were conducted at 3 and 12 months. After a mean of 11.6 ± 9 months, 45 patients (56%) remained in SR. At 12 months, 56% of patients with baseline moderate or worse MR improved to mild MR. Among those in SR, this rose to 77% versus 38% with AF recurrence. Only patients in SR showed significant improvements in LVEF, left atrial size, and heart failure symptoms. Similarly, 54% of patients with at least moderate TR at baseline improved to mild TR at 12 months. Among those maintaining SR, 70% showed TR improvement, compared to 35% with recurrent AF. Right ventricular function (TAPSE, RV diameter/volume) improved only in those in SR.
conclusionRestoring and maintaining SR led to significant reductions in MR and TR severity and cardiac remodeling. These findings support rhythm control as a key therapeutic strategy in patients with AF and functional MR/TR.
Indexed as
Identifiers
41711811What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.