Evidence map›Paper›PMID 41711745›Full record

ArticleESC heart failure2026

Sex differences in patients with advanced heart failure: an analysis of the HELP-HF registry.

Mauro Riccardi, Chiara Tedino, Mauro Chiarito, Davide Stolfo, Luca Baldetti, Daniela Tomasoni, Riccardo Maria Inciardi, Marianna Adamo, Alessandro Villaschi, Ferdinando Loiacono and 13 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Mauro RiccardiDivision of Cardiology, Cremona Hospital, Largo Priori Emilio, 1, Cremona 26100, Italy.ORCID 0009-0009-3444-1916
Chiara TedinoInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Viale Europa 11, Brescia 25123, Italy.
Mauro ChiaritoDepartment of Cardiovascular Medicine, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy.ORCID 0000-0002-9333-2658
Davide StolfoDivision of Cardiology, Cardiothoracic Department, Azienda Sanitaria Universitaria Integrata Friuli Centrale, Udine, Italy.ORCID 0000-0002-4538-6811
Luca BaldettiCardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Daniela TomasoniInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Viale Europa 11, Brescia 25123, Italy.ORCID 0000-0002-7584-2857
Riccardo Maria InciardiInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Viale Europa 11, Brescia 25123, Italy.
Marianna AdamoInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Viale Europa 11, Brescia 25123, Italy.ORCID 0000-0002-3855-1815
Alessandro VillaschiDepartment of Cardiovascular Medicine, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy.
Ferdinando LoiaconoDepartment of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Marta MaccalliniDepartment of Cardiovascular Medicine, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy.
Gaia GaspariniDepartment of Cardiovascular Medicine, Humanitas Research Hospital IRCCS, Rozzano, Milan, Italy.
Stefano ContessiCardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.
Daniele CocianniCardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.
Maria PerottoCardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.
Giuseppe BaroneCardiac Intensive Care Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Marco MerloCardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.ORCID 0000-0002-1022-3131
Alberto Maria CappellettiHead of the Outpatient Service of General and Territorial Cardiology, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Gianfranco SinagraCardiovascular Department, Azienda Sanitaria Universitaria Giuliano Isontina (ASUGI), University of Trieste, Trieste, Italy.
Daniela PiniCardiology Unit, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy.
Marco MetraInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Viale Europa 11, Brescia 25123, Italy.ORCID 0000-0001-6691-8568
Matteo PagnesiInstitute of Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, Spedali Civili di Brescia, Viale Europa 11, Brescia 25123, Italy.ORCID 0000-0002-9298-7871
Carlo Mario LombardiDivision of Cardiology, Cremona Hospital, Largo Priori Emilio, 1, Cremona 26100, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSex differences are reported in patients with heart failure (HF), but gaps remain in clinical practice and evidence, in particular, in those with advanced HF.

methodsThe HELP-HF registry enrolled consecutive patients with HF and at least one high-risk 'I NEED HELP' marker, evaluated at four Italian centres between 1 January 2020 and 30 November 2021. Patients' characteristics and outcomes were compared in men vs women. The primary endpoint was the composite of all-cause mortality or first HF hospitalization.

resultsA total of 1149 patients were included (mean age 75.1 ± 11.5 years, median left ventricular ejection fraction 35%). Among them, 773 patients (67.3%) were males. Males were younger, had more cardiovascular diseases and a lower left ventricular ejection fraction (32%, [interquartile range 25-45] vs 45% [interquartile range 30-55]), while females showed a higher prevalence of non-cardiac conditions, neurocognitive and depressive disorders. The 1-year rate of the primary composite endpoint was 43.2% in males and 43.1% in females (log-rank P = .857). Multivariable analysis confirmed the lack of a significant impact of sex on the primary endpoint (adjusted hazard ratio 1.03, 95% confidence interval 0.85-1.27, P = .740). No significant differences were also observed in men vs women for the individual endpoints.

conclusionsIn our registry enrolling patients with markers of advanced HF, despite differences in clinical and echocardiographic characteristics, no sex-related differences in clinical outcomes were observed.

Indexed as

Heart FailureRegistriesStroke VolumeVentricular Function, LeftAgedAged, 80 and overFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedPrognosisRisk FactorsSex FactorsSurvival RateAdvanced heart failureDifferencesHELP-HFMortalitySex

Identifiers

PMID41711745
PMCPMC13108298

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