Evidence map›Paper›PMID 41711721›Full record

ArticleESC heart failure2026

Non-dilated left ventricular cardiomyopathy in patients with chronic Chagas disease and heart failure with reduced left ventricular ejection fraction.

Reinaldo B Bestetti, Augusto Cardinalli-Neto, Ana Paula Otaviano, Mauricio N Machado, Paulo R Pavarino, Marcelo A Nakazone

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Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Reinaldo B BestettiDepartment of Medicine, University of Ribeirão Preto, Ribeirão Preto city 14096-900, Brazil.ORCID 0000-0002-4488-9601
Augusto Cardinalli-NetoFundação Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto city, Brazil.
Ana Paula OtavianoFundação Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto city, Brazil.ORCID 0000-0002-3745-0297
Mauricio N MachadoFundação Faculdade de Medicina de São José do Rio Preto, São José do Rio Preto city, Brazil.
Paulo R PavarinoDepartment of Cardiology and Cardiovascular Surgery, São José do Rio Preto Medical School, São José do Rio Preto city, Brazil.
Marcelo A NakazoneDivision of Postgraduation, São José do Rio Preto Medical School, São José do Rio Preto city, Brazil.ORCID 0000-0002-0449-7056

Funding

University of Ribeirão Preto
6 · The paper itself

Abstract

introductionThe aim of this investigation was to establish the clinical characteristics and outcomes of patients with non-dilated left ventricular cardiomyopathy (NDLVC) secondary to chronic Chagas disease (CChD).

methodsAll patients with CChD followed at our institution from January 2000 to January 2010 were included. Patients with a left ventricular ejection fraction (LVEF) <50%, a left ventricular diastolic diameter (LVDD) <55 mm, and segmental wall motion abnormalities (SWMA) on echocardiography were diagnosed with NDLVC secondary to CChD. The remaining patients had dilated cardiomyopathy (DCM) secondary to CChD.

resultsOf the 215 patients, 21 (10%) had NDLVC. In this group, the mean age was 62 ± 9 years, 12 (57%) were male, the median daily dose of metoprolol was 100 (62, 5, 125) mg, the LVDD was 51 ± 29 mm, and the LVEF was 39 ± 6.4%. SWMA were found in 12 (57%) patients. Mean follow-up 50.8 ± 3.8 months, during which 9 (43%) patients died. In a Cox regression model, Beta-blocker therapy was the only independent predictor of all-cause mortality for patients with NDLVC (hazard ratio = 0.16, 95% CI 0.04-0.68; P = .01) Over a 60-month follow-up, Kaplan-Meier survival estimates at 12, 24, 36, 48, and 60 months, were 71%, 71%, 59%, 59%, and 59%, respectively, in patients with NDLVC, and 77%, 61%, 49%, 38%, and 30%, respectively, in those with DCM due to CChD (P = .04).

conclusionsNon-dilated left ventricular cardiomyopathy affects one in 10 patients with CHF due to CChD, and the 5-year survival rate is 59%.

Indexed as

Chagas CardiomyopathyHeart FailureHeart VentriclesStroke VolumeVentricular Dysfunction, LeftVentricular Function, LeftChronic DiseaseEchocardiographyFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesSurvival RateChagas cardiomyopathyChagas diseaseHeart failureInherited cardiomyopathyNon-dilated left ventricular cardiomyopathy

Identifiers

PMID41711721
PMCPMC13108309

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