Evidence map›Paper›PMID 41711714›Full record

ArticleESC heart failure2026

Urinary sodium to guide diuretic therapy in acute heart failure: results of a national survey.

Marta Cobo Marcos, Joan Carles Trullàs, Jose Perez-Silvestre, Òscar Miró, Borja Quiroga, Sonia Mirabet, Gregorio Romero-González

Abstract readMulticenter Study
In one paragraph

Article in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marta Cobo MarcosCardiology Department, Hospital Universitario Puerta de Hierro, C/Joaquín Rodrigo 2, 28222, Madrid, Spain.ORCID 0000-0002-9026-061X
Joan Carles TrullàsInternal Medicine Department, Hospital dOlot i comarcal de la Garrotxa, Girona, Spain.ORCID 0000-0002-7380-3475
Jose Perez-SilvestreInternal Medicine Department, Consorcio Hospital General Universitario de Valencia, Valencia, España.
Òscar MiróDepartment of Emergency, Hospital Clínic, 'Processes and Pathologies, Emergencies Research Group' IDIBAPS, University of Barcelona, Barcelona, Spain.ORCID 0000-0002-7924-9751
Borja QuirogaIIS-La Princesa, Nephrology Department, Hospital Universitario de la Princesa, RICORS-renal 2040, Madrid, Spain.ORCID 0000-0001-5730-1929
Sonia MirabetCentro de Investigación Biomédica en Red (CIBER) Cardiovascular, C/ Monforte de Lemos 3-5, Pabellón 11, 28029 Madrid, Spain.ORCID 0000-0001-5955-2748
Gregorio Romero-GonzálezNephrology Department, Medicine Department, University Hospital Germans Trias i Pujol, (HGiTP) & REMAR-IGTP Group, Germans Trias i Pujol Research Institute (IGTP), Universitat Autònoma de Barcelona, Can Ruti Campus, Badalona, Spain.ORCID 0000-0001-7481-3678

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsUrinary sodium (uNa+) is a promising tool to guide diuretic therapy in acute heart failure (AHF), yet its real-world adoption is uncertain. We aimed to evaluate current practices, perceived utility, and barriers to uNa⁺-guided management among physicians managing AHF in Spain.

methodsWe conducted a nationwide cross-sectional electronic survey in June 2025 of clinicians from cardiology, internal medicine, emergency medicine, and nephrology. The questionnaire assessed the frequency and timing of uNa+ monitoring in inpatient and outpatient settings, thresholds for poor response, therapeutic adjustments, and perceived benefits and barriers.

resultsA total of 413 physicians responded: 138 (33%) from cardiology, 159 (39%) from internal medicine, 78 (19%) from emergency medicine, and 38 (9%) from nephrology. Overall, 70% reported measuring uNa+ during AHF hospitalization, but only 18% did so routinely. Outpatient application remained infrequent (32%). Nephrologists showed the highest usage in both inpatient (90%) and outpatient (61%) settings. The most frequent cut-off to define diuretic resistance was <50 mmol/l. Therapeutic strategies differed by specialty: loop diuretic escalation was more frequent in cardiology and emergency medicine, while thiazides were preferred in internal medicine and nephrology. Most participants (78%) considered uNa⁺ monitoring clinically useful. Major barriers included lack of standardized protocols, limited training, therapeutic inertia, and logistical constraints.

conclusionsWhile uNa⁺ monitoring is valued by clinicians, its use in AHF in Spain remains inconsistent across specialties. Addressing implementation barriers through education, protocols, and decision-support tools is critical to a broader adoption of uNa⁺ guided therapy in routine care.

Indexed as

DiureticsHeart FailureSodiumAcute DiseaseBiomarkersCross-Sectional StudiesFemaleHumansMaleSpainSurveys and QuestionnairesBiomarkersDiureticsSodiumAcute heart failureNatriuresisuNa+Urinary sodium

Identifiers

PMID41711714
PMCPMC13108265

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.