Evidence map›Paper›PMID 41711495›Full record

ArticleActa oncologica (Stockholm, Sweden)2026

Outcome of resectable distal cholangiocarcinoma in a single-centre Western patient cohort: comparison of the 7th and 8th edition of the UICC/AJCC TNM classification.

Maia Blomhoff Holm, Sondre Busund, Rahul Rihel, Mushegh A Sahakyan, Ivar Prydz Gladhaug, Caroline S Verbeke, Sheraz Yaqub, Dyre Kleive

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta oncologica (Stockholm, Sweden), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maia Blomhoff HolmDepartment of Pathology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-3680-0259
Sondre BusundDepartment of HPB Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0009-0002-8477-6406
Rahul RihelInstitute of Clinical Medicine, University of Oslo, Oslo, Norway.
Mushegh A SahakyanThe Intervention Center, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Department of Surgery, Ringerike Hospital, Vestre Viken Hospital Trust, Ringerike, Norway; Department of Surgery N1, Yerevan State Medical University, Yerevan, Armenia.ORCID 0000-0002-4815-7694
Ivar Prydz GladhaugDepartment of HPB Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0003-1441-6288
Caroline S VerbekeDepartment of Pathology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-1111-9715
Sheraz YaqubDepartment of HPB Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.ORCID 0000-0002-5696-2319
Dyre KleiveDepartment of HPB Surgery, Rikshospitalet, Oslo University Hospital, Oslo, Norway. dyrkle@ous-hf.no.ORCID 0000-0002-7072-8422

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeDistal cholangiocarcinoma (CCA) is a rare malignancy with poor prognosis, even after surgical resection. Accurate staging is essential for guiding treatment and predicting outcomes. The 8th edition of the Union for International Cancer Control (UICC)/The American Joint Committee on Cancer (AJCC) TNM classification introduced depth of tumour invasion (DOI) as the criterion for T-staging (T1-T3) and a three-tiered lymph node (N) classification. This study evaluates patient stratification and prognostic accuracy of the 8th versus 7th edition in a single-centre Western cohort and discusses difficulties with measuring DOI. Patient/material and methods: Patients undergoing pancreatoduodenectomy for distal CCA at Oslo University Hospital (2015-2021) were retrospectively analysed. Tumours were restaged according to the 7th and 8th TNM editions. Survival was assessed using Kaplan-Meier estimates and log-rank tests to compare prognostic accuracy.

resultsSeventy-one patients were included. Using the 7th edition, most cancers (94.4%, 67 patients) were categorised as T3. With the 8th edition, stage redistribution was notable: T2 included 45 patients (63.4%) and T3 included 22 (31.0%). Five-year survival was significantly better for T2 (31.8%) than T3 (10.5%) according to the 8th edition, demonstrating improved discrimination. The revised N classification provided better prognostic distinction, with median survival of 30 months for N1 (1-3 nodes) and 23 months for N2 (≥4 nodes).

interpretationThe 8th edition provides more accurate prognostic stratification of distal CCA compared to the 7th edition but requires meticulous, standardised pathology assessment to ensure accurate prognosis and appropriate post-surgical management.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaNeoplasm StagingAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPancreaticoduodenectomyPrognosisRetrospective Studies

Identifiers

PMID41711495
PMCPMC12931082

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