Evidence map›Paper›PMID 41711444›Full record

ReviewJournal of virology2026

Impact of cellular proteases on the function of antiviral antibodies.

Mateo Krzypow, Olivier Schwartz, Timothée Bruel, Andréa Cottignies-Calamarte

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mateo KrzypowAntiviral Activities of Antibodies Group, Virus and Immunity Unit, Département de Virologie, Institut Pasteur, Paris, France.ORCID 0009-0009-0291-8556
Olivier SchwartzAntiviral Activities of Antibodies Group, Virus and Immunity Unit, Département de Virologie, Institut Pasteur, Paris, France.
Timothée BruelAntiviral Activities of Antibodies Group, Virus and Immunity Unit, Département de Virologie, Institut Pasteur, Paris, France.ORCID 0000-0002-3952-4261
Andréa Cottignies-CalamarteAntiviral Activities of Antibodies Group, Virus and Immunity Unit, Département de Virologie, Institut Pasteur, Paris, France.ORCID 0000-0002-1041-4659

Funding

Agence Nationale de la Recherche ANR-23-CE15-0039-01Agence Nationale de Recherches sur le Sida et les Hépatites Virales D25266Vaccine Research Center ANR-10-LABX-77
6 · The paper itself

Abstract

Viruses evade antibodies through many mechanisms. While mutation remains the predominant pathway, host proteases can be hijacked upon viral infections and decrease antibody-mediated clearance. Proteolysis can degrade or shed viral antigens to create soluble decoys, induce conformational changes that reduce neutralization, and cleave Fc receptors and complement proteins, hindering Fc-effector antibody functions. This review synthesizes evidence on the interplay between viruses and host proteases to evade antiviral activities of antibodies.

Indexed as

Antibodies, ViralImmune EvasionPeptide HydrolasesVirus DiseasesVirusesAnimalsHost-Pathogen InteractionsHumansProteolysisAntibodies, ViralPeptide Hydrolasesantibodyimmune escapeproteasesvirus

Identifiers

PMID41711444
PMCPMC13011384

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.