ArticleHaemophilia : the official journal of the World Federation of Hemophilia
Central Nervous System Bleeding in Children With Haemophilia in Limited Resource.
Article in Haemophilia : the official journal of the World Federation of Hemophilia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCentral nervous system (CNS) bleeding in children with haemophilia is a life-threatening complication that may cause severe neurological sequelae or death. In resource-limited settings, where prophylaxis is not universally accessible, its patterns and outcomes may differ from those in high-income countries.
aimsTo describe the clinical characteristics, management and outcomes of paediatric haemophilia patients with CNS bleeding.
methodsThis retrospective descriptive study reviewed 19 children with haemophilia who developed CNS bleeding.
resultsThe median age at onset was 1.8 years (range, 0.4-14.3). Seventeen patients had Haemophilia A (11 severe, 4 moderate, 2 mild), and two had Haemophilia B (1 severe, 1 moderate). Three Haemophilia A patients developed high-titre inhibitors with recurrent intracerebral haemorrhage (ICH). Bleeding types included ICH (13), subdural haemorrhage (8), subarachnoid haemorrhage (3), intraventricular haemorrhage (1), epidural haematoma (1), subgaleal haematoma (1) and spinal epidural haematoma (1). Most events were spontaneous (17), while trauma (5) and lumbar puncture (2) were reported precipitating causes. Presentations included seizures (12), altered consciousness (13), headache/vomiting (8) and back pain (1). Four children were newly diagnosed with Haemophilia A at the time of CNS bleeding. Six required craniotomy, while others without inhibitors were successfully managed with factor replacement. Outcomes included death (4), developmental delay (5), hemiparesis (3) and full recovery (10). Deaths were mainly associated with delayed recognition and treatment.
conclusionEarly recognition of CNS bleeding is essential for timely factor replacement and improved survival. Key strategies include caregiver education, healthcare provider training, streamlined emergency pathways and wider access to prophylaxis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.