Evidence map›Paper›PMID 41711008›Full record

ArticleThe Analyst2026

Studying the evolutionary potential of ancestral aryl sulfatases in the alkaline phosphatase family with droplet microfluidics.

Bernard D G Eenink, Josephin M Holstein, Magdalena Heberlein, Carina Dilkaute, Joachim Jose, Florian Hollfelder, Bert van Loo, Erich Bornberg-Bauer, Tomasz S Kaminski, Andreas Lange

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Analyst, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bernard D G EeninkInstitute for Evolution and Biodiversity, University of Münster, Germany. andreas.lange@uni-muenster.de.ORCID http://orcid.org/0000-0002-6111-5667
Josephin M HolsteinDepartment of Biochemistry, University of Cambridge, UK.
Magdalena HeberleinInstitute for Evolution and Biodiversity, University of Münster, Germany. andreas.lange@uni-muenster.de.
Carina DilkauteInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany.
Joachim JoseInstitute of Pharmaceutical and Medicinal Chemistry, University of Münster, Germany.ORCID http://orcid.org/0000-0002-0666-2676
Florian HollfelderDepartment of Biochemistry, University of Cambridge, UK.ORCID http://orcid.org/0000-0002-1367-6312
Bert van LooDepartment of Applied Sciences, Northumbria University, Newcastle-upon-Tyne, UK.ORCID http://orcid.org/0000-0003-4253-2163
Erich Bornberg-BauerInstitute for Evolution and Biodiversity, University of Münster, Germany. andreas.lange@uni-muenster.de.ORCID http://orcid.org/0000-0002-1826-3576
Tomasz S KaminskiDepartment of Molecular Biology, Institute of Biochemistry, Faculty of Biology, University of Warsaw, Warsaw, Poland. ts.kaminski2@uw.edu.pl.ORCID http://orcid.org/0000-0001-5124-4548
Andreas LangeInstitute for Evolution and Biodiversity, University of Münster, Germany. andreas.lange@uni-muenster.de.ORCID http://orcid.org/0000-0003-3871-1986

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Characterizing the dynamics and functional shifts during protein evolution is essential, both for understanding protein evolution and for rationalizing efficient strategies for

Indexed as

Alkaline PhosphataseArylsulfatasesEvolution, MolecularMicrofluidic Analytical TechniquesMicrofluidicsMutationAlkaline PhosphataseArylsulfatases

Identifiers

PMID41711008
PMCPMC12917725

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.