ArticleFrontiers in immunology2026
An isoflavone-enriched diet alleviates Parkinson's disease in mice by inhibiting ferroptosis through gut microbiota-mediated serotonin production.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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5 authors.
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Abstract
Objective: Parkinson's disease (PD) is a severe neurodegenerative disorder whose pathogenesis is closely linked to gut microbiota dysregulation. However, whether and how modulation of gut homeostasis can ameliorate PD remains unclear. Dietary isoflavones have been associated with neuroprotective effects and show strong potential in shaping the composition of the gut microbiota, yet their underlying mechanisms in PD are poorly understood. Methods: Microbiomics and non-targeted metabolomics were utilized to characterize microbial community composition and metabolic alterations in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced mouse model of PD. Subsequently, both the MPTP-induced PD mouse model and Results: Here, we show that an isoflavone-enriched diet alleviates motor deficits and dopaminergic neuron loss in an MPTP-induced mouse model of PD. This protective effect is mediated via a gut-brain axis mechanism: isoflavones promote the expansion of intestinal Conclusions: Our findings reveal a novel dietary-microbiota-serotonergic pathway that mitigates ferroptosis and neurodegeneration, highlighting the therapeutic potential of isoflavone-based interventions for PD.
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