ArticleFrontiers in immunology2026
Aberrant STAT3 activation and overproduction of IL-21 in systemic lupus erythematosus: role of miR-155 and miR-21 in target genes
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Myeloid-Derived Suppressor Cells in Inflammatory Arthritis.International journal of molecular sciences · 2026Review
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Authors and funding
10 authors.
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Abstract
Introduction: SLE is a chronic autoimmune disease characterized by immune system dysregulation, including aberrant activation of B and T lymphocytes and overproduction of proinflammatory cytokines such as IL-21. Through the STAT3 signaling pathway, this cytokine plays a key role in SLE-promoting autoantibody production and immune imbalance. It has been reported that miRNAs, such as miR-155 and miR-21, could be overexpressed in SLE and contribute to the STAT3 pathway dysregulation. We aimed to analyze the association between miR-155 and miR-21 and the expression of Materials and methods: PBMC isolation was performed by density gradient centrifugation using Histopaque-1077, culture overnight, and seeded at a concentration of 1x10 Results: Our results showed an increased expression of miR-155 and miR-21 in SLE patients compared to HC in both, stimulated and non-stimulated PBMC. The increased miR-155 and miR-21 expression were associated with a decreased gene expression of Discussion: These findings highlight the association between miR-155 and miR-21 with target genes SOCS1, PTEN, and PIAS3, that may contribute to the aberrant activation of the STAT3 pathway and the overproduction of IL-21 in SLE patients.
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