ReviewCureus2026
Endometrial Autologous Intrauterine Platelet-Rich Plasma (PRP) Instillation Treatment and Its Potential on In Vitro Fertilization (IVF): Narrative Review.
Review in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Platelet-Rich Plasma in Recurrent Pregnancy Loss: Toward a Precision Medicine Framework for Biologically Guided Patient Selection.Medical sciences (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantation failure remains a major challenge in assisted reproductive technology, particularly in women with thin endometrium, repeated implantation failure (RIF), Asherman's syndrome (AS), or chronic endometritis (CE). In recent years, autologous intrauterine platelet-rich plasma (PRP) has been proposed as a regenerative approach aimed at improving endometrial receptivity through the local release of growth factors, cytokines, and angiogenic mediators. A narrative review of the literature published between 2015 and 2021 was performed using PubMed, Google Scholar, and Web of Science. Studies assessing intrauterine PRP administration in women undergoing assisted reproduction were included. Due to the limited availability of high-quality randomized evidence, data from a wide range of study designs-including randomized controlled trials, observational studies, pilot studies, and case reports-were reviewed in order to reflect current clinical experience. Reported outcomes included endometrial thickness, implantation rate, clinical pregnancy rate, and live birth rate in patients with thin endometrium, RIF, AS, and CE. Most studies described an association between PRP administration and improvements in endometrial thickness, vascularity, implantation, and clinical pregnancy rates. In women with thin endometrium, PRP was frequently associated with an increase in endometrial thickness to at least 7 mm and improved reproductive outcomes. In cases of repeated implantation failure, some randomized controlled trials suggested higher pregnancy and implantation rates in PRP-treated patients compared with controls. Evidence regarding AS and CE was largely derived from case reports and small case series, reporting enhanced endometrial regeneration and occasional successful pregnancies. Overall, intrauterine PRP appears to be a promising and well-tolerated autologous intervention for women with poor prognostic factors. Nevertheless, the available evidence remains preliminary, and further large-scale randomized controlled trials using standardized PRP preparation and administration protocols are required to clarify its effectiveness and define its role in evidence-based assisted reproduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.