ArticleCureus2026
Primary Central Nervous System Lymphoma With Testicular and Prostatic Involvement: A Case Report.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diffuse large B-cell lymphoma (DLBCL) is an aggressive subtype of non-Hodgkin lymphoma that most commonly presents with nodal disease, while primary involvement of the central nervous system (CNS) is rare, particularly in immunocompetent patients. We describe the case of a 41-year-old immunocompetent male who presented with progressive left-sided hemiparesis, ipsilateral facial palsy, severe headache, and decreased level of consciousness. Neuroimaging findings and histopathological examination confirmed the diagnosis of primary CNS DLBCL. Subsequent systemic evaluation with PET-CT revealed increased metabolic activity in the testicular and prostatic regions, consistent with secondary extranodal involvement. The patient was treated with a MATRIX-based chemotherapy regimen, including high-dose methotrexate, cytarabine, and rituximab, in accordance with current guidelines for primary CNS lymphoma. This case highlights an unusual presentation of primary CNS DLBCL with early systemic dissemination to testicular and prostatic tissue, underscoring the importance of comprehensive staging and prompt initiation of high-dose methotrexate-based therapy to optimize clinical outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.