ArticleFrontiers in pediatrics2025
Comparison of 2005 and 2024 diagnostic criteria for early identification of pediatric sepsis and septic shock in PICU patients: a prospective cohort study.
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Outcomes of robotic-assisted soave pull-through procedure for Hirschsprung disease: a systematic review and meta-analysis.Journal of robotic surgery · 2026Pooled it
- Review
- Care Pathway and Outcomes in Pediatric Septic Shock: A Narrative Review from Emergency Department Recognition to PICU Management.Children (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: In 2024, new international consensus criteria for pediatric sepsis and septic shock (2024 criteria) were introduced, replacing the 2005 criteria. The 2024 criteria use the Phoenix Sepsis Score (PSS) to define sepsis (score ≥2) and septic shock (cardiovascular PSS ≥1) in children with suspected infection, moving away from the 2005 reliance on systemic inflammatory response syndrome (SIRS). This study compares the two criteria in terms of diagnostic consistency, disease severity, prognosis, and early identification. Methods: Pediatric patients with infection admitted to the PICU at the Capital Institute of Pediatrics from May 2023 to May 2025 were prospectively enrolled. Those diagnosed with sepsis within 0-6 h of admission were included. Data on demographics, infection sites, pathogens, laboratory markers (platelets, albumin, creatinine, lactate), organ dysfunction scores (PCIS), and clinical outcomes (mechanical ventilation, CRRT, MODS, DIC, mortality) were collected. Diagnostic agreement was assessed using Kappa statistics, and performance was compared using McNemar's test. The 2005 criteria served as the reference for calculating sensitivity, specificity, and predictive values of the 2024 criteria. Results: The 2024 criteria identified fewer sepsis (80 vs. 240) and septic shock (49 vs. 86) cases. Diagnostic agreement was poor (Kappa = 0.161, Conclusions: The 2024 sepsis criteria improve specificity but may overlook early septic shock. The 2024 septic shock criteria are stricter, potentially delaying diagnosis and treatment. Prospective studies and AI-supported early warning models are needed for better early identification and outcomes.
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