ArticleACS pharmacology & translational science2026
Bioisosteric Replacement of Amides with 1,2,3-Triazoles Improves Dopamine D4 Receptor Ligand Pharmacokinetics.
Abstract read
In one paragraph
Article in ACS pharmacology & translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Investigating substituted phenylacetamide ligands in the DBioorganic & medicinal chemistry letters · 2026Article
- Novel dopamine 4 receptor ligands differentially ameliorate ADHD-like behaviors in spontaneously hypertensive rats.Psychopharmacology · 2026Article
- Recent Developments in Ferulic Acid- and Caffeic Acid-Based Hybrids with Potential Anticancer Properties.Molecules (Basel, Switzerland) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Mohammad AlkhatibDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Franziska M JakobsDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States.ORCID https://orcid.org/0000-0003-2861-8868
John N HansonMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States.
Ashley N NilsonMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States.
Amy E MoritzMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States.
Tian LiDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States.
Afua B FaibilleDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States.
Lindsay A BournDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States.
Peter A RamdhanDepartment of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, Florida 32610, United States.ORCID https://orcid.org/0000-0002-2027-1591
Joseph RicchezzaDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.ORCID https://orcid.org/0009-0002-2795-8406
Shannon JordanDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.ORCID https://orcid.org/0009-0006-2581-1741
Diandra PanasisDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Norman NguyenDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Nitish KasarlaDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Bryant WangDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Sergio Sola GarciaDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
Julianna SaezDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.
James PauleDepartment of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States.
Chae Bin LeeDepartment of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States.ORCID https://orcid.org/0000-0003-4551-9191
Rana RaisDepartment of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States.ORCID https://orcid.org/0000-0003-4059-2453
Barbara S SlusherDepartment of Neurology, Johns Hopkins Drug Discovery, The Johns Hopkins University School of Medicine, 855 N. Wolfe Street, Baltimore, Maryland 21205, United States.ORCID https://orcid.org/0000-0001-9814-4157
David R SibleyMolecular Neuropharmacology Section, National Institute of Neurological Disorders and Stroke-Intramural Research Program, National Institutes of Health, Bethesda, Maryland 20892, United States.ORCID https://orcid.org/0000-0002-0624-962X
Chenglong LiDepartment of Medicinal Chemistry, University of Florida College of Pharmacy, 1345 Center Drive, Gainesville, Florida 32610, United States.
Thomas M KeckDepartment of Chemistry & Biochemistry, Department of Biological & Biomedical Sciences, College of Science and Mathematics, Rowan University, 201 Mullica Hill Road, Glassboro, New Jersey 08028, United States.ORCID https://orcid.org/0000-0003-1845-9373
Comfort A BoatengDepartment of Basic Pharmaceutical Sciences, Fred Wilson School of Pharmacy, High Point University, One University Parkway, High Point, North Carolina 27268, United States.ORCID https://orcid.org/0000-0003-1907-431X
Funding
Molecular And Pharmacological Studies Of Dopamine ReceptorsZIANS002263 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI SIBLEY, DAVID · 2009 to 2025
$37.4MU-Rise at Rowan UniversityT34GM136492 · NIGMS · ROWAN UNIVERSITY · PI KECK, THOMAS MCGOWAN, NUCCI, NATHANIEL V · 2021 to 2025
$2.0MDevelopment of High-Affinity and Selective Ligands as a Pharmacological Tool for the Dopamine D4 Receptor (D4R) Subtype VariantsDP1DA058385 · NIDA · HIGH POINT UNIVERSITY · PI Comfort Ahenkan Boateng · 2023 to 2026
$1.8MLow-Efficacy Dopamine D4 Receptor Partial Agonists for Cocaine AddictionR21DA050896 · NIDA · HIGH POINT UNIVERSITY · PI BOATENG, COMFORT AHENKAN, KECK, THOMAS MCGOWAN · 2020 to 2021
$428kIntramural NIH HHS ZIA NS002263NIDA NIH HHS DP1 DA058385NIDA NIH HHS R21 DA050896NIGMS NIH HHS T34 GM136492
Abstract
Dopamine D4 receptor (D
Indexed as
1,2,3-triazoleagonistantagonistbioisosteredopamine D4 receptorpharmacokinetics
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.