Evidence map›Paper›PMID 41710727›Full record

ArticleReproductive and developmental medicine2026

Uterine epithelial estrogen receptor α temporally regulates preimplantation uterine immunity involving interleukin-1β signaling.

Jonathan Matthew Hancock, Taylor Elijah Martin, Yuehuan Li, Skyler Owens-Gonzalez, Tong Zhou, Declan James Gresham, Wendy Tharpe Watford, Xiaoqin Ye

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive and developmental medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jonathan Matthew HancockDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Taylor Elijah MartinDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Yuehuan LiDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Skyler Owens-GonzalezDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Tong ZhouDepartment of Physiology and Cell Biology, University of Nevada, Reno School of Medicine, Reno, NV 89509, USA.
Declan James GreshamDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Wendy Tharpe WatfordDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Xiaoqin YeDepartment of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Estrogen receptor α (ERα/ Methods: Uterine tissues and uterine flushes were collected from naturally mated uterine epithelial ERα-deficient Results: There was a sharp decline in neutrophils from D0.5 to D3.5 in both Conclusion: These findings demonstrate an essential function of uterine epithelial ERα in controlling mating-induced inflammation in the LE layer, stromal layer, and uterine lumen, and highlight the IL-1β signaling pathway among the molecular mechanisms involved in regulation of uterine inflammation by uterine epithelial ERα.

Indexed as

Early pregnancyIL-1β SignalingInflammationNeutrophilUterine epithelial ERα

Identifiers

PMID41710727
PMCPMC12911493

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.