ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2026
Association of Central Obesity and Diabetes with Thyroid Nodules: A 3.2-year Prospective Study in Chinese Adults.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Association of age, BMI and their interaction with thyroid nodules in patients with type 2 diabetes mellitus: a cross-sectional study.Frontiers in endocrinology · 2026Article
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11 authors.
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Abstract
Purpose: We investigated the association of central obesity and glucose metabolism with thyroid nodule (TN) risk and explored whether diabetes/central obesity altered TN risk. Methods: Data were collected in the Risk Evaluation of cAncers in Chinese diabeTic Individuals: a lONgitudinal study, which involved cross-sectional (May-August 2011) and longitudinal cohorts (July-October 2014; 3.2-year follow-up). In all, 8995 subjects were enrolled in the baseline survey; the 5655 subjects evaluated during the 3.2-year follow-up were included in this study. All subjects underwent body measurements, laboratory tests, and thyroid ultrasonography. Results: Among 5655 participants, 420 had TNs. Participants with central obesity or abnormal glucose metabolism had significantly higher TN risk than participants without central obesity (OR: 1.233; 95% CI: 1.009-1.507) or abnormal glucose metabolism (OR: 1.257; 95% CI: 1.025-1.541). After adjustments for age and sex, this significance was retained for central obesity. Among participants with central obesity, prediabetes (OR: 1.483, 95% CI: 1.016-2.163) and diabetes (OR: 1.622, 95% CI: 1.078-2.407) were associated with TNs, when compared to the euglycemic subgroup ( Conclusion: TNs are associated with central obesity and abnormal glucose metabolism. Chronic/new-onset central obesity increased TN risk. New-onset prediabetes/diabetes amplified TN risk among people with chronic central obesity.
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