ArticleJournal of hepatocellular carcinoma2026
Electroacupuncture and Moxibustion Regulate Aerobic Glycolysis and Alleviate Tumor Progression in Mice with Hepatocellular Carcinoma.
Article in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: Aerobic glycolysis is crucial in the proliferation, metastasis, immunosuppression of hepatocellular carcinoma (HCC). We established mice model with HCC to explore whether electroacupuncture and moxibustion can alleviate HCC mice by inhibiting NSUN2-mediated aerobic glycolysis. Methods: HCC mice model was established by intraperitoneal injection of diethylnitrosamine combined with carbon tetrachloride. In the moxibustion and electroacupuncture groups, the acupoints "Ganshu" and "Zusanli" (bilateral) were selected for intervention. Enzyme-linked immunosorbent assay quantified the serum levels. Immunohistochemistry/Western blotting, quantitative real-time PCR assessed protein and mRNA expressions of aerobic glycolysis. MRM-based targeted metabolomics quantified hepatic energy metabolism alterations. Results: After HCC model completion on week 28, macroscopic examination revealed pronounced hepatomegaly with evident morphological distortion. The hepatic surface exhibited a coarse and irregular texture, accompanied by varying degrees of adhesions between adjacent liver lobes. Notably, large, well-defined tumors presenting in either whitish or dark-red appearances were observed scattered across the liver parenchyma. Following a total intervention period of 26 weeks, electroacupuncture and moxibustion significantly decreased the number of liver tumor, tumor load, mean tumor diameter and tumor volume compared to the model group ( Conclusion: The study reveals that both electroacupuncture and moxibustion alleviate tumor proliferation in HCC mice by suppressing the NSUN2-PKM2 glycolytic axis, thereby highlighting this pathway as a novel metabolic target for non-pharmacological intervention; moreover, moxibustion uniquely exhibits the potential to induce a more extensive metabolic stress response. The observed reductions in tumor burden and key biomarkers corroborate the therapeutic potential of this approach. Collectively, these preclinical findings suggest that electroacupuncture and moxibustion, as non-pharmacological adjunctive therapies, hold translational potential for modulating tumor metabolism and slowing HCC progression, warranting further clinical investigation.
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