ArticleJournal of hepatocellular carcinoma2026
Comparing Minimally Invasive Puncture Under Local Anesthesia to Open Laparotomy Under General Anesthesia for Establishing a Rabbit VX2 Liver Tumor Model.
Article in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
Funding
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Abstract
Purpose: To compare ultrasound-guided percutaneous puncture under local anesthesia (LA) versus open laparotomy under general anesthesia (GA) for establishing a rabbit VX2 liver tumor model, evaluating efficacy, safety, animal welfare, and tumor biology. Methods: Twenty-eight rabbits were randomly assigned to Group A (ultrasound-guided percutaneous under LA, n = 14) or Group B (open surgery under GA, n = 14). Parameters compared included anesthesia and operation time, intraoperative blood loss, surgical trauma, postoperative complications, mortality, tumor implantation success rate, tumor volume, and tumor characteristics were evaluated via imaging and histopathological analysis. Results: Compared to Group B, Group A demonstrated significantly shorter anesthesia preparation time (61.00 ± 6.70 s vs 632.60 ± 67.84 s, Conclusion: Ultrasound-guided percutaneous puncture under LA is a superior method for creating the VX2 liver model. It is faster, less invasive, reduces bleeding and tumor dissemination risk, maintains equivalent tumorigenicity, and better adheres to animal welfare principles.
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