ArticleFrontiers in oncology2026
Metabolic Bulk Volume is an independent prognostic factor and facilitates identifying high risk cases for DLBCL patients treated with the R-CHOP.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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- Erratum issued
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Abstract
Objective: The purpose of this study was to evaluate the prognostic value of metabolic bulk volume (MBV), a baseline 18-fluorode-oxyglucose positron emission computed tomography ( Methods: 311 consecutive newly diagnosed Diffuse Large B-Cell Lymphoma (DLBCL) patients were retrospectively evaluated. Estimating MBV, Distance between the centers of the two farthest lesions (Dmax) and Total metabolic tumour volume (TMTV) as semiquantitative metabolic parameters. Receiver Operating Characteristic (ROC) curve analysis was used to determine the optimal cut-off values. Progression-Free Survival (PFS) and Overall Survival (OS) were the endpoints for evaluating prognosis. PFS and OS were estimated using Kaplan-Meier curves, and comparisons were performed via log-rank test. Results: Multivariate analysis showed that only two baseline Conclusion: MBV was an independent prognostic factor for DLBCL patients. The combination of MBV with parameters reflecting tumor dissemination distribution or total tumor burden further improved the risk stratification for staging in DLBCL patients.
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