ArticleFrontiers in oncology2026
Association of B7H3 with HIF-1α nuclear expression indicates poor prognosis and therapeutic potential in gastric cancer.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
B7H3 (B7 homolog 3) is an important immune checkpoint molecule in the B7-CD28 family, and substantial evidence indicates that it promotes tumor growth, invasion, and metastasis. The imbalance between oxygen supply and consumption in the tumor microenvironment induces hypoxia, which activates hypoxia-inducible factor-1α (HIF-1α) signaling. HIF-1α plays a critical role in tumor growth, metastasis, and immune evasion. However, the interaction between HIF-1α and B7H3 in gastric cancer remains unclear. In this study, we explored the expression characteristics and correlation of B7H3 and HIF-1α in large gastric cancer samples using bioinformatics and immunohistochemical methods. The results show that B7H3 and HIF-1α mRNA are significantly upregulated in gastric cancer, with a strong positive correlation between their expressions. In gastric cancer tissues, no significant correlation was found between B7H3 and HIF-1α expression (r
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