ArticleCanadian respiratory journal2026
The Value of the Near-Infrared Fluorescent Probe ErNP@SiO2-ICG in the Diagnosis of Malignant Pleural Effusion.
Article in Canadian respiratory journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Value of the Near-Infrared Fluorescent Probe ErNP@SiO2-ICG in the Diagnosis of Malignant Pleural Effusion.Canadian respiratory journal · 2026Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives: Malignant pleural effusions (MPEs) present a significant clinical challenge and are associated with a poor prognosis, frequently observed in patients with advanced malignancies. Conventional diagnostic techniques for identifying MPEs exhibit limitations in both accuracy and sensitivity. To differentiate between benign and MPEs, the clinical applicability of the ErNP@SiO2-ICG rare earth nano-nano near-infrared (NIR) fluorescence probe was investigated. Methods: Through solution chemistry processes, vacuum treatment with heat, and the synthesis of a core-shell design, an exceptional rare earth nano NIR fluorescent probe was developed in this study, which showed the capacity to target tumors precisely. After that, a prospective research was conducted with a cohort of 90 patients; 20 of them were excluded because of unclear diagnoses. Every participant had a thoracoscopic biopsy for histological analysis, a cytological assessment of pleural effusions, and an evaluation of the recently developed dyes. R programming, GraphPad Prism, and Microsoft Excel were used when carrying out statistical inspection of the obtained data. Results: ErNP@SiO2-ICG particles experienced a size of 176.1 ± 0.2 nm. Their emission peak was located at 550 nm in relation to their fluorescence spectra, and their scanning electron microscopy image demonstrated uniform particle size and distribution with NIR fluorescence characteristics. The optimum time and concentration for color development were 2 μL and 1 h, respectively. The fluorescence imaging and cytological investigation of pleural effusions differed significantly ( Conclusion: The ErNP@SiO2-ICG rare earth-doped nano-probe for NIR fluorescence imaging exhibits exceptional accuracy in the detection of MPE, thereby providing an innovative technological approach for the future identification of this condition.
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