Evidence map›Paper›PMID 41710561›Full record

Articlenpj health systems2026

Accelerating AI innovation in healthcare: real-world clinical research applications on the Mayo Clinic Platform.

Yue Yu, Xinyue Hu, Sivaraman Rajaganapathy, Jingna Feng, Ahmed Abdelhameed, Xiaodi Li, Jianfu Li, Xiaoke Liu, Liu Yang, Nilüfer Ertekin-Taner and 9 more

Abstract read
In one paragraph

Article in npj health systems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yue YuDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Xinyue HuDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Sivaraman RajaganapathyDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Jingna FengDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Ahmed AbdelhameedDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Xiaodi LiDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Jianfu LiDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Xiaoke LiuDepartment of Cardiovascular Medicine, Mayo Clinic Health System, La Crosse, WI USA.
Liu YangDivision of Hepatology and Liver Transplant, Mayo Clinic, Jacksonville, FL USA.
Nilüfer Ertekin-TanerDepartment of Neurology, Mayo Clinic, Jacksonville, FL USA.
Phil FieroMayo Clinic Platform, Rochester, MN USA.
Soulmaz BoroumandMayo Clinic Platform, Rochester, MN USA.
Richard LarsenMayo Clinic Platform, Rochester, MN USA.
Maneesh GoyalMayo Clinic Platform, Rochester, MN USA.
Clark C OtleyMayo Clinic Platform, Rochester, MN USA.
Nansu ZongDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.
Vijay H ShahDivision of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN USA.
John D HalamkaMayo Clinic Platform, Rochester, MN USA.
Cui TaoDepartment of Artificial Intelligence and Informatics, Mayo Clinic, Jacksonville, FL USA.

Funding

Peripheral and Central Biomarkers of Alzheimer's Disease in Diverse CohortsU19AG074879 · NIA · MAYO CLINIC JACKSONVILLE · PI NILUFER ERTEKIN-TANER · 2023 to 2026
$42.0M
Integrating the exposome and methylome to inform brain molecular changes in ADRD across established diverse cohorts.U01AG046139 · NIA · UNIVERSITY OF FLORIDA · PI ERTEKIN-TANER, NILUFER, FUNK, CORY · 2013 to 2022
$24.6M
Integrative translational discovery of vascular risk factors in aging and dementiaRF1AG051504 · NIA · MAYO CLINIC JACKSONVILLE · PI BU, GUOJUN, ERTEKIN-TANER, NILUFER · 2015 to 2019
$9.8M
Harnessing Molecular Networks of Resilience for Therapeutic Discoveries in ADR01AG061796 · NIA · MAYO CLINIC JACKSONVILLE · PI ERTEKIN-TANER, NILUFER · 2018 to 2022
$5.7M
ACTS (AD Clinical Trial Simulation): Developing Advanced Informatics Approaches for an Alzheimer's Disease Clinical Trial Simulation SystemR01AG084236 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Jiang Bian, Cui Tao · 2023 to 2026
$4.1M
An end-to-end informatics framework to study Multiple Chronic Conditions (MCC)'s impact on Alzheimer's disease using harmonized electronic health recordsR01AG083039 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BIAN, JIANG, JIANG, XIAOQIAN · 2023 to 2025
$3.4M
Facilitate Observational Studies of Alzheimer's Disease and Alzheimer's Disease-Related Dementias Using Ontology and Natural Language ProcessingRF1AG072799 · NIA · YALE UNIVERSITY · PI LIU, HONGFANG, TAO, CUI · 2021 to 2021
$2.4M
ACCELERATE-BASSO: Coordinating Center for Accelerating Behavioral and Social Science through OntologyU24AG088019 · NIA · UNIVERSITY OF FLORIDA · PI Jiang Bian, Mark A Musen · 2024 to 2026
$2.3M
Standardizing and Harmonizing Behavioral and Social Science Research Factors in Alzheimer's Disease through Ontology-Based ApproachesU01AG088076 · NIA · MAYO CLINIC JACKSONVILLE · PI Jiang Bian, Cui Tao · 2024 to 2026
$2.3M
BOND: Benchmarking based on heterogeneous biOmedical Network and Deep learning novel drug-target associationsR00GM135488 · NIGMS · MAYO CLINIC ROCHESTER · PI ZONG, NANSU · 2021 to 2023
$747k
NIA NIH HHS R01 AG061796NIA NIH HHS R01 AG083039NIA NIH HHS R01 AG084236NIA NIH HHS RF1 AG051504NIA NIH HHS RF1 AG072799NIA NIH HHS U01 AG046139NIA NIH HHS U01 AG088076NIA NIH HHS U19 AG074879NIA NIH HHS U24 AG088019NIGMS NIH HHS R00 GM135488
6 · The paper itself

Abstract

Artificial intelligence (AI) holds promise for healthcare, but real-world implementation remains difficult. The Mayo clinic platform (MCP) addresses this by providing scalable, multi-institutional, de-identified data and analytical tools. Through four research projects, we demonstrate MCP's ability to support efficient cohort identification, AI model development, and real-world evidence generation. MCP enables broader accessibility and standardization compared to institutional EHRs, positioning it as a powerful platform for advancing translational research and precision medicine.

Indexed as

Business and industryComputational biology and bioinformaticsHealth careMedical researchScientific community

Identifiers

PMID41710561
PMCPMC12909107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.