Evidence map›Paper›PMID 41710542›Full record

ReviewBiochemistry research international2026

NADPH-Related Enzymes and Cancer: Facts and Insights Into the Application of Immunohistochemistry.

Camila M Scudeler, Keila Samantha da Silva, Rafaela V N Silva, Adilha M R Micheletti, Karen B Ribeiro, Juliana Reis Machado, Régia C P Lira

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Biochemistry research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camila M ScudelerDepartment of Pathology, Genetics and Evolution, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, uftm.edu.br.ORCID https://orcid.org/0000-0002-7143-8523
Keila Samantha da SilvaDepartment of Gynecology and Obstetrics of Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, usp.br.ORCID https://orcid.org/0000-0001-9318-6489
Rafaela V N SilvaDepartment of Pathology, Genetics and Evolution, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, uftm.edu.br.ORCID https://orcid.org/0000-0003-4120-036X
Adilha M R MichelettiDepartment of Surgical Clinic, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, uftm.edu.br.ORCID https://orcid.org/0000-0003-2101-0366
Karen B RibeiroDepartment of Clinical Oncology, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, uftm.edu.br.ORCID https://orcid.org/0000-0002-6501-5639
Juliana Reis MachadoDepartment of Pathology, Genetics and Evolution, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, uftm.edu.br.ORCID https://orcid.org/0000-0002-8673-7788
Régia C P LiraDepartment of Pathology, Genetics and Evolution, Federal University of Triângulo Mineiro, Uberaba, Minas Gerais, Brazil, uftm.edu.br.ORCID https://orcid.org/0000-0002-1217-3852

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During tumorigenesis and metastasis, cancer cells initiate antioxidant defense mechanisms to prevent irreversible damage, thereby sustaining tumor growth. The functionality of reactive oxygen species (ROS)-scavenging proteins is dependent on nicotinamide adenine dinucleotide phosphate (NADPH), which is regulated by specific metabolic enzymes, which are described as potential biomarkers of cancer aggressiveness. Immunohistochemistry (IHC) is one of the most accessible and widely utilized techniques to augment the pathological diagnosis of cancer. Hence, this review addresses the protein expression of NADPH-related enzymes, as assessed by IHC, and their associations with human cancer progression factors (overall survival, tumor staging, metastasis, and recurrence). Studies indicate that glucose-6-phosphate dehydrogenase (G6PD), along with malic enzymes and methylenetetrahydrofolate dehydrogenase 2 (MTHFD2), represents the most pertinent enzymes examined through IHC concerning cancer aggressiveness. The immunolabeling method produced consistent results for this group of enzymes, which might lead to successful application in predicting tumor prognosis. Other NADPH-related enzymes, such as glutamate dehydrogenase (GDH), aldehyde dehydrogenase 1 (ALDH1), and dihydrofolate reductase (DHFR), deserve more extensive investigation to elucidate their potential as cancer biomarkers via IHC.

Indexed as

cancerenzymesimmunohistochemistryNADPH

Identifiers

PMID41710542
PMCPMC12910181

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.