Evidence map›Paper›PMID 41710405›Full record

ArticleFrontiers in endocrinology2026

Association between chronic stress-related amygdala metabolic activity and distant metastasis in colorectal cancer.

Hyun Joo Kim, Sejin Ha, Chanmin Joung, Sungeun Kim, Kisoo Pahk

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Hyun Joo Kim *Department of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Sejin Ha *Division of Nuclear Medicine, Department of Radiology, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Chanmin JoungGraduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, United States.
Sungeun KimDepartment of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.
Kisoo PahkDepartment of Nuclear Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Chronic stress has been implicated in cancer progression through neuroendocrine and inflammatory pathways, but its role in colorectal cancer (CRC) remains uncertain. The amygdala, a key stress-responsive brain structure, demonstrates measurable metabolic activity on Patients and methods: This study included patients with newly diagnosed CRC who underwent pre-treatment ¹ Results: Seventy-six patients were analyzed, of whom 21 (27.6%) had distant metastasis. AmygA was significantly higher in patients with distant metastasis than in those without (1.17 ± 0.06 vs. 1.08 ± 0.06; Conclusions: Elevated amygdala metabolic activity on pre-treatment ¹

Indexed as

AmygdalaColorectal NeoplasmsStress, PsychologicalAgedFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedNeoplasm MetastasisPositron Emission Tomography Computed TomographyRadiopharmaceuticalsFluorodeoxyglucose F18Radiopharmaceuticalsamygdalacolorectal cancermetastasispositron emission tomographystress

Identifiers

PMID41710405
PMCPMC12909207

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.