ArticleJournal of pain research2026
Analgesic Efficacy of a Novel Traditional Chinese Medicine Ointment Against Mechanical Allodynia in Rat Models.
Article in Journal of pain research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: Effective management of procedure-related pain, such as venipuncture, is a critical clinical need. The Eutectic Mixture of Local Anesthetics (EMLA) cream is a standard topical analgesic but has limitations including contraindications and potential adverse effects. The Cortex Erythrinae formula recorded in the Golden Mirror of Medicine is traditionally used to dispel wind-dampness, unblock collaterals, and relieve arthralgia. Objective: This study aimed to develop a novel Traditional Chinese Medicine (TCM) ointment based on classical prescriptions and to evaluate its efficacy against mechanical allodynia, using EMLA cream as a positive control. Methods: Fifty male Sprague-Dawley rats were randomly allocated to five groups (n=10). Mechanical allodynia was induced; the mechanical withdrawal threshold (MWT), pain-related behaviors, skin irritation, and systemic toxicity were assessed following topical application of low-, medium-, or high-concentration TCM ointment, EMLA cream, or blank vehicle. Results: High-concentration TCM ointment significantly elevated MWT ( Conclusion: The high-concentration TCM ointment provided rapid (within 20 min), superior, and cost-effective analgesia with an excellent safety profile, suggesting its promise as an alternative to EMLA for managing mechanical allodynia.
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