ArticleFrontiers in nutrition2026
Prognostic value of the creatinine-to-albumin ratio for 28-day mortality in patients with sepsis and diabetes: integrating renal and nutritional status in the ICU.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Association of blood urea nitrogen to albumin ratio with short-term mortality in critically ill patients with urosepsis.Frontiers in medicine · 2026Article
- Association between lactate dehydrogenase-to-albumin ratio and short-term mortality in critically ill patients with urosepsis: evidence from dual retrospective cohorts.Frontiers in cellular and infection microbiology · 2026Article
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5 authors.
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Abstract
Background: Patients with sepsis and diabetes exhibit complex pathophysiology that greatly increases the risk of adverse outcomes. This study aimed to investigate the association between CAR and 28-day all-cause mortality among intensive care unit (ICU) patients with sepsis and diabetes mellitus. Methods: In this retrospective cohort study based on the eICU-CRD, we analyzed 1,800 adult patients with sepsis and diabetes mellitus, who were stratified into quartiles by admission CAR. Survival was assessed by Kaplan-Meier analysis. Covariates were selected via LASSO and stepwise regression. Multivariate Cox models evaluated CAR's independent association with mortality. Restricted cubic splines explored nonlinear relationships. ROC analysis and subgroup analyses were performed. Results: Multivariate Cox proportional hazards analysis indicated that CAR was significantly correlated with the 28-day mortality risk in the ICU. Patients in the highest quartile (Q4) had a 4.68-fold greater risk of death compared with those in the lowest quartile [HR 4.68, 95% CI 2.55-8.61, Conclusion: CAR was associated with increased 28-day mortality in ICU patients with sepsis and diabetes. These findings suggest that CAR may be useful for prognosis assessment and risk stratification.
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