Evidence map›Paper›PMID 41710065›Full record

ArticleNAR molecular medicine2026

Identification of enzymatically modified isoquercitrin as a therapeutic lead for myotonic dystrophy type 1.

Subodh K Mishra, Sawyer M Hicks, Jesus A Frias, Jing Zhang, Mark T Handley, Sweta Vangaveti, Tammy S Reid, Aradhana Pandey, Omari McMichael, Christopher Crumbaugh and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Subodh K MishraThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Sawyer M HicksThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Jesus A FriasThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Jing ZhangThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Mark T HandleyThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Sweta VangavetiThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.ORCID https://orcid.org/0000-0002-2274-9544
Tammy S ReidThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Aradhana PandeyThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.
Omari McMichaelCenter for Inherited Myology Research, Virginia Commonwealth University, Richmond, VA 23298, United States.
Christopher CrumbaughCenter for Inherited Myology Research, Virginia Commonwealth University, Richmond, VA 23298, United States.
Marina ProvenzanoCenter for Inherited Myology Research, Virginia Commonwealth University, Richmond, VA 23298, United States.
Melissa A HaleCenter for Inherited Myology Research, Virginia Commonwealth University, Richmond, VA 23298, United States.
Nicholas E JohnsonCenter for Inherited Myology Research, Virginia Commonwealth University, Richmond, VA 23298, United States.
Masayuki NakamoriDepartment of Neurology, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.ORCID https://orcid.org/0000-0003-4714-3044
John D ClearyThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.ORCID https://orcid.org/0000-0001-7599-5995
Kaalak ReddyThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.ORCID https://orcid.org/0000-0002-1916-0261
J Andrew BerglundThe RNA Institute, College of Arts and Sciences, University at Albany, State University of New York, Albany, NY 12222, United States.ORCID https://orcid.org/0000-0002-5198-2724

Funding

Senator Paul D. Wellstone Muscular Dystrophy Specialized Research CenterP50NS048843 · NINDS · UNIVERSITY OF ROCHESTER · PI THORNTON, CHARLES A · 2018 to 2022
$7.1M
Training CoreP50AR085906 · NIAMS · VIRGINIA COMMONWEALTH UNIVERSITY · PI Nicholas Elwood Johnson · 2025 to 2026
$4.1M
Design, Synthesis and Efficacy of New Small Molecule Therapeutics to Impede Myotonic DystrophyR01NS120485 · NINDS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Andrew Berglund, Masayuki Nakamori · 2022 to 2026
$2.7M
RNA Science and Technology in Health and DiseaseT32GM132066 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Thomas J Begley · 2019 to 2026
$1.8M
Zeiss LSM 980 Confocal Microscope SystemS10OD028600 · OD · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI VALM, ALEX M · 2022 to 2022
$477k
NIAMS NIH HHS P50 AR085906NIGMS NIH HHS T32 GM132066NIH HHS S10 OD028600NINDS NIH HHS P50 NS048843NINDS NIH HHS R01 NS120485
6 · The paper itself

Abstract

Myotonic dystrophy type 1 (DM1) is a complex multisystemic disease caused by a CTG repeat expansion in the

Identifiers

PMID41710065
PMCPMC12910114

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.