ArticleFrontiers in physiology2025
Computational physiological modeling for lung-specific ventilation and perfusion management in
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Introduction: Methods: We developed and validated a computational physiological model (CPM) of lungs on EVLP. The CPM integrates established principles of lung mechanics, gas exchange, and perfusion with clinical input data. It provides mechanistic insight into Results: Simulation results closely aligned with clinical measurements of left atrial partial oxygen pressure (root mean squared error (RMSE) of 6.4 mmHg). Sensitivity analysis and uncertainty quantification further elucidated key determinants of oxygen and carbon dioxide dynamics, including the inspired oxygen fraction, intrapulmonary shunt, dead space, and perfusate flow. Discussion: This CPM enhances understanding of
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