ArticleYonago acta medica2026
Rice Bran Attenuates Liver Fibrosis Caused by Vitamin E Deficiency in the Pre-Aging Stage.
Article in Yonago acta medica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Vitamin E (VE) is a fat-soluble vitamin and well-known as an antioxidant. VE deficiency is associated with various oxidative stress- and aging-related pathologies and sufficient VE intake is thought to help prevent these conditions. However, it has been unclear how VE deficiency in the pre-aging stage affects the liver. In the present study, 11-month-old mice were fed a VE-restricted diet for 3 months, when age-related changes began to appear, to examine the effects of VE deficiency on the liver. Compared to the livers of mice fed a standard diet, those fed a VE-deficient diet showed metabolic dysfunction-associated steatohepatitis (MASH)-like findings including fibrosis. Mice fed the VE-deficient diet mixed with 2% rice bran (RB) showed milder fibrosis than those fed the VE-deficient diet alone. These results suggest that VE deficiency in the pre-aging stage may cause MASH-like changes in the liver, particularly fibrosis, and that RB is an effective means of supplying VE.
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