ArticleFrontiers in medicine2026
Association between red blood cell distribution width to albumin ratio and prognosis in patients with sepsis-associated acute kidney injury: a retrospective cohort study.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The red blood cell distribution width-to-albumin ratio (RAR) has shown prognostic value in sepsis, diabetes comorbidities, and cancer (CA). However, its relevance to clinical outcomes in sepsis-associated acute kidney injury (SA-AKI) remains unclear. This study aimed to explore this relationship. Methods: A retrospective cohort study was conducted on SA-AKI patients admitted to the Intensive Care Unit of Baise People's Hospital, Guangxi, from May 2022 to May 2025. The primary endpoint was 28-day all-cause mortality. The prognostic utility of RAR was assessed using multivariable Cox regression, restricted cubic splines (RCS), Kaplan-Meier survival curves with log-rank tests, stratified analysis, receiver operating characteristic (ROC) curves, subgroup, and sensitivity analyses. Results: Among the 161 enrolled patients (mean age 63.7 ± 16.6 years), the mean RAR was 6.95 ± 2.81%/g/dl. A linear association between RAR and mortality was observed (non-linearity Conclusion: Elevated RAR independently predicts adverse early prognosis in SA-AKI, with higher levels correlating with increased 28-day mortality. The combination of RAR and LAR significantly improves mortality prediction in this cohort.
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