Evidence map›Paper›PMID 41709596›Full record

ArticleNeurocase2026

Mixed primary progressive aphasia and alcohol use disorder: a case of detailed clinical phenotyping outperforming molecular imaging.

Obiora Okoye, Cristiano Schaffer Aguzzoli, Petronilla Battista, Claudia Ramos, Karen Meenan, Maison Abu Raya, Buddhika Ratnasiri, Julio C Rojas, Jessica de Leon, Bruce Miller and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurocase, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Obiora OkoyeGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Cristiano Schaffer AguzzoliGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-7378-3830
Petronilla BattistaGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Claudia RamosGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Karen MeenanGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Maison Abu RayaGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Buddhika RatnasiriGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Julio C RojasGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Jessica de LeonGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Bruce MillerGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.ORCID 0000-0002-2152-4220
Maria Luisa Gorno-TempiniGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Renaud La JoieGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.
Salvatore SpinaGlobal Brain Health Institute, Memory and Aging Center, University of California San Francisco, San Francisco, CA.ORCID 0000-0003-3570-9143

Funding

National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8M
TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
Research Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Primary Progressive Aphasia: Cognition, Anatomy and ProgressionRF1NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2022 to 2022
$4.7M
Word fluency task performance as a marker of Alzheimer’s disease in Tagalog/English bilingual speakerR01AG080396 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jessica Anne Deleon · 2023 to 2026
$3.3M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
Proteomics for fluid biomarker discovery in frontotemporal dementiaK23AG059888 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROJAS-MARTINEZ, JULIO CESAR · 2019 to 2023
$995k
Primary Progressive Aphasia: Beyond the Clinical VariantsK23DC018021 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DELEON, JESSICA ANNE · 2020 to 2024
$995k
NIA NIH HHS K23 AG059888NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG080396NIA NIH HHS U24 AG021886NIDCD NIH HHS K23 DC018021NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915NINDS NIH HHS RF1 NS050915
6 · The paper itself

Abstract

Primary progressive aphasia (PPA) refers to a group of clinically and pathologically heterogeneous syndromes characterized by progressive and relatively selective impairment in speech and language as the main cognitive domain in the early disease stage. The main clinical variants of PPA based on current diagnostic criteria include logopenic variant PPA (lvPPA), nonfluent variant PPA (nfvPPA), and semantic variant PPA (svPPA). Identification of speech/language and non-language abilities and

Indexed as

AlcoholismAphasia, Primary ProgressiveAgedBrainFemaleHumansMagnetic Resonance ImagingNeuropsychological TestsPhenotypePositron-Emission Tomographyalcohol use disorderAlzheimer’s disease neuropathologylogopenic variant PPAPrimary progressive aphasia (PPA)semantic variant PPAβ-amyloid PET imaging

Identifiers

PMID41709596
PMCPMC13180464

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.