Evidence map›Paper›PMID 41709579›Full record

ArticlePlant communications2026

The plasma membrane ABC transporter Sl-ABCB5 mediates acylsugar secretion from tomato trichomes to confer insect resistance.

Tao Lyu, Leiqin Han, Jianfeng Jin, Jianjing Wang, Huiyan Zhou, Xiaoyan Xu, Shan Feng, Jingquan Yu, Robert L Last, Pengxiang Fan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tao LyuDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Leiqin HanDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Jianfeng JinDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Jianjing WangDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Huiyan ZhouDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Xiaoyan XuMass Spectrometry & Metabolomics Core Facility, The Biomedical Research Core Facility, Westlake University, Hangzhou 310030, China.
Shan FengMass Spectrometry & Metabolomics Core Facility, The Biomedical Research Core Facility, Westlake University, Hangzhou 310030, China.
Jingquan YuDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China.
Robert L LastDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824, USA; Department of Plant Biology, Michigan State University, East Lansing, MI 48824, USA.
Pengxiang FanDepartment of Horticulture, Zijingang Campus, Zhejiang University, Hangzhou 310058, China; Key Laboratory of Horticultural Plant Growth and Development, Ministry of Agriculture of China, Hangzhou 310058, China. Electronic address: pxfan@zju.edu.cn.

Funding

Non-US Government Research Support type
6 · The paper itself

Abstract

Acylsugars are structurally diverse specialized metabolites secreted by glandular trichomes of Solanaceae plants and play a crucial role in defense against herbivores and pathogens. However, the mechanism underlying acylsugar secretion remains unclear. This study identifies and characterizes the plasma membrane ATP-binding cassette (ABC) transporter Sl-ABCB5 as a key component mediating acylsugar transport in trichome secretory cells of cultivated tomato (Solanum lycopersicum). Using CRISPR-Cas9-generated Sl-ABCB5 knockout mutants, we observed a dramatic reduction in trichome acylsugar accumulation, accompanied by increased susceptibility to western flower thrips (Frankliniella occidentalis). In vitro transport assays using membrane vesicles and protoplasts confirmed the ability of Sl-ABCB5 to transport acylsugars. Furthermore, virus-induced gene silencing and CRISPR-mediated knockout of ABCB5 orthologs in wild tomato (Solanumpennellii) and black nightshade (Solanum nigrum) demonstrated functional conservation of this transporter across Solanaceae species. Together, these findings reveal a conserved acylsugar transport mechanism and establish ABCB5 as a promising target for engineering enhanced insect resistance in Solanaceae crops.

Indexed as

ATP-Binding Cassette TransportersPlant ProteinsSolanum lycopersicumThysanopteraTrichomesAnimalsCell MembraneATP-Binding Cassette TransportersPlant ProteinsABC transporteracylsugarglandular trichomeinsect resistance

Identifiers

PMID41709579
PMCPMC13370232

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.