Evidence map›Paper›PMID 41709524›Full record

ArticleCPT: pharmacometrics & systems pharmacology2026

Physiologically Based Pharmacokinetic Virtual Twin Approach for Fludarabine Dosing in Pediatric Hematopoietic Stem Cell Transplantation.

Mourad Mseddi, Christa Nath, Khalil Ben Hassine, Vid Mlakar, Yvonne Gloor, Fanny Gonzales, Chakradhara Rao S Uppugunduri, Youssef Daali, Steven Keogh, Marc Ansari

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CPT: pharmacometrics & systems pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mourad MseddiCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-8936-1600
Christa NathDepartment of Biochemistry, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID https://orcid.org/0000-0002-1013-3646
Khalil Ben HassineCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0001-6760-8377
Vid MlakarCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0003-4968-5592
Yvonne GloorCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-8790-0479
Fanny GonzalesCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0009-0007-5883-391X
Chakradhara Rao S UppugunduriCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-8928-7049
Youssef DaaliClinical Pharmacology and Toxicology Division, University Hospitals of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-8391-9383
Steven KeoghThe Cancer Centre for Children, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.ORCID https://orcid.org/0009-0000-7412-9091
Marc AnsariCANSEARCH Research Platform for Pediatric Oncology and Hematology, Department of Pediatrics, Gynecology, and Obstetrics, University of Geneva, Geneva, Switzerland.ORCID https://orcid.org/0000-0002-9649-6498

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fludarabine (Flu), administered as a prodrug Flu monophosphate, is a lymphodepleting agent used prior to hematopoietic stem cell transplantation (HSCT) which exhibits substantial pharmacokinetics (PK) variability, contributing to suboptimal outcomes. This study developed and validated a physiologically based pharmacokinetic (PBPK) model using literature-based data and a middle-out approach for Flu and its two main metabolites in adults and children, and evaluated its performance to predict individual Flu exposures in 28 pediatric HSCT patients using a virtual twin (VT) approach using PK-Sim software. Different informed models with individual demographic and biological characteristics were assessed by comparing predicted and observed plasma exposures (AUC

Indexed as

Antineoplastic AgentsHematopoietic Stem Cell TransplantationModels, BiologicalVidarabineAdolescentAdultArea Under CurveChildChild, PreschoolComputer SimulationFemaleHumansInfantMaleAntineoplastic AgentsfludarabineVidarabinechemotherapyfludarabinehematopoietic stem cell transplantationpediatricphysiologically based pharmacokineticsvirtual twins

Identifiers

PMID41709524
PMCPMC12962397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.