Evidence map›Paper›PMID 41709508›Full record

ArticleInternational journal of stem cells2026

STOML2 Maintains Pluripotency and Cell Cycle Integrity in Human Pluripotent Stem Cells via PHB-ERK Signaling.

Yena Song, Bomi Kim, Ahyeon Kim, Dongyue No, Jeong Bin Lee, Hyun Kyu Kim, Jae Sang Oh, Sung-Hwan Moon, Dong-Yun Shin, Youngsok Choi and 1 more

Abstract read
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In one paragraph

Article in International journal of stem cells, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yena SongSoonchunhyang Institute of Medi-bio Science, Soon Chun Hyang University, Cheonan, Korea.ORCID https://orcid.org/0000-0002-8451-4847
Bomi KimDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology & The Institute of Advanced Regenerative Science, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0009-0008-1528-5295
Ahyeon KimDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology & The Institute of Advanced Regenerative Science, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0009-0008-1500-9602
Dongyue NoDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology & The Institute of Advanced Regenerative Science, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0009-0002-7199-3874
Jeong Bin LeeDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology & The Institute of Advanced Regenerative Science, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0009-0001-7719-7468
Hyun Kyu KimSoonchunhyang Institute of Medi-bio Science, Soon Chun Hyang University, Cheonan, Korea.ORCID https://orcid.org/0000-0001-5141-931X
Jae Sang OhDepartment of Neurosurgery, Uijeongbu St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.ORCID https://orcid.org/0000-0003-4570-6763
Sung-Hwan MoonDepartment of Animal Science and Technology, Chung-Ang University, Anseong, Korea.ORCID https://orcid.org/0000-0003-1858-0261
Dong-Yun ShinAnimal Assisted Care, Ansan University, Ansan, Korea.ORCID https://orcid.org/0009-0003-0168-6868
Youngsok ChoiDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology & The Institute of Advanced Regenerative Science, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0000-0002-3862-4105
Man Ryul LeeDepartment of Stem Cell and Regenerative Biotechnology, KU Institute of Science and Technology & The Institute of Advanced Regenerative Science, Konkuk University, Seoul, Korea.ORCID https://orcid.org/0000-0002-2351-9679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human pluripotent stem cells (hPSCs) can self-renew indefinitely and differentiate into all three germ layers. However, the primary regulators of hPSC cell cycle dynamics remain unclear. To identify novel regulators of hPSC proliferation, transcriptomic profiling of undifferentiated hPSCs and somatic cells was performed via next-generation sequencing. Stomatin-like protein 2 (STOML2) and prohibitin (PHB) were among the upregulated genes in hPSCs and were closely associated with the extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) signaling pathway. Temporal expression analysis indicated that STOML2 and PHB decreased during differentiation and increased during reprogramming. Short hairpin RNA (shRNA)-mediated knockdown of STOML2 in hPSCs caused phenotypic changes. Gene expression analyses demonstrated reduced OCT4, NANOG, PHB, and phosphorylated ERK, alongside increased differentiation markers across all three germ layers. The STOML2-PHB axis is essential for maintaining hPSC identity by sustaining ERK/MAPK activity and cell cycle structure. This study identified STOML2 as a key pluripotency regulator and provides new insight into intrinsic stem cell fate control.

Indexed as

Cell cycle regulationHuman pluripotent stem cellReprogrammingStemnessSTOML2

Identifiers

PMID41709508
PMCPMC13218843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.