Evidence map›Paper›PMID 41709439›Full record

ArticleGut microbes2026

Bacterial constipation: Mucin-degrading intestinal commensal bacteria cause constipation.

Tomonari Hamaguchi, Noriaki Gibo, Misuzu Ohara, Mikako Ito, Tomoyuki Ogura, Jun-Ichi Takeda, Hiroshi Nishiwaki, Fei Zhao, Ryo Kinoshita-Daitoku, Masashi Hattori and 8 more

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tomonari HamaguchiDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-1028-7012
Noriaki GiboDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0003-1448-3835
Misuzu OharaDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0009-0001-2567-5376
Mikako ItoDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-1351-7602
Tomoyuki OguraCentral Institute for Experimental Medicine and Life Science, Kawasaki, Japan.ORCID 0009-0002-2482-1076
Jun-Ichi TakedaDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0001-5367-5608
Hiroshi NishiwakiDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-5203-5884
Fei ZhaoDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0009-0000-1659-2141
Ryo Kinoshita-DaitokuDepartment of Bacteriology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0009-0000-5365-0734
Masashi HattoriDepartment of Gastroenterology, Yamashita Hospital, Ichinomiya, Japan.ORCID 0000-0002-4021-1051
Koji NonogakiDepartment of Gastroenterology, Daido Hospital, Nagoya, Japan.
Tetsuya MaedaDivision of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Iwate, Japan.ORCID 0000-0002-6207-8343
Kenichi KashiharaOkayama Neurology Clinic, Okayama, Japan.ORCID 0000-0002-1815-9832
Yoshio TsuboiDepartment of Neurology, Long-term Observation Research, Juntendo University, Tokyo, Japan.ORCID 0000-0002-6758-0981
Masaaki HirayamaDepartment of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0003-0092-7837
Mitsuhiro FujishiroDepartment of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-4074-1140
Hiroki KawashimaDepartment of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-3720-781X
Kinji OhnoDivision of Neurogenetics, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-1529-2750

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The contribution of gut microbes to constipation remains mechanistically underexplored, despite constipation being one of the most prevalent gastrointestinal disorders. Here, we identify cooperative induction of constipation by two mucin-degrading gut commensals:

Indexed as

Bacteroides thetaiotaomicronConstipationGastrointestinal MicrobiomeMucinsAkkermansiaAnimalsFecesFemaleGerm-Free LifeHumansMaleMiceMice, Inbred C57BLSulfatasesMucinsSulfatasesAkkermansia muciniphilaBacterial constipationBacteroides thetaiotaomicronchronic idiopathic constipationgnotobiotic micemucin degradationParkinson's diseasesulfatase

Identifiers

PMID41709439
PMCPMC12928629

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.