ArticleJournal of translational medicine2026
Single-cell atlas of hepatic cellular plasticity and immune niche reprogramming in liver cirrhosis.
Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Exploring the mechanism by which triphenyl phosphate promotes malignant phenotypes in bladder and kidney cancer through MMP9 based on bioinformatics analysis and experimental validation.Clinical and experimental medicine · 2026Article
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundCirrhosis is a severe liver disease characterized by inflammation, fibrosis, and immune dysregulation. This study exploits publicly available single-cell sequencing datasets to decipher disease-relevant specific immune cell subtypes, their gene expression profiles and altered transcription factor activity in cirrhosis, aiming to understand their roles in disease onset and progression.
methodsTo investigate the dynamic changes and underlying mechanisms of immune cells in cirrhosis, we employed a comprehensive bioinformatics approach integrating several advanced tools and analytical methods. Single-cell RNA sequencing data were processed and analyzed using Seurat for cell clustering and annotation. Monocle was used for pseudotime trajectory analysis to explore cellular differentiation pathways. CellChat enabled the assessment of cell‒cell communication networks among immune populations. Additionally, we conducted single-cell regulatory network inference to identify key transcriptional regulators. Immune response enrichment analysis (IREA) was performed to evaluate immune-related functional pathways, providing deeper insights into the immune landscape and disease progression in cirrhosis.
resultsWe analyzed 35,017 cells, identifying 21 clusters and 12 major immune cell types. Macrophages, CD4
conclusionThe analysis revealed three key axes influencing disease-related immune regulation: TNF-α/ETS2-driven polarization of macrophages toward a Mac-d phenotype, IL-1α/β/THRA-associated polarization of CD4
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