Evidence map›Paper›PMID 41709294›Full record

ArticleJournal of nanobiotechnology2026

Supramolecular delivery of senolytics enables targeted anti-senescence therapy and accelerated fracture healing.

Yonggang Fan, Ze-Han Wang, Xu Zhang, Yu Dong, Xin Liu, Gan Luo, Houzhi Yang, Huinan Li, Zicheng Wang, Qiong Tang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yonggang Fan *School of Medicine, Nankai University, Tianjin, China.
Ze-Han Wang *College of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, China.
Xu Zhang *School of Medicine, Nankai University, Tianjin, China.
Yu DongSchool of Medicine, Nankai University, Tianjin, China.
Xin LiuTianjin Medical University, Tianjin, China.
Gan LuoTianjin Medical University, Tianjin, China.
Houzhi YangTianjin Medical University, Tianjin, China.
Huinan LiDepartment of Spinal Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, 300121, China.
Zicheng WangSchool of Medicine, Nankai University, Tianjin, China.
Qiong TangDepartment of Respiratory, Tianjin Union Medical Center, Tianjin, 300121, China.
Xin JinSchool of Medicine, Nankai University, Tianjin, China. xin.jin@nankai.edu.cn.
Dong-Sheng GuoCollege of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering, Frontiers Science Center for New Organic Matter, Nankai University, Tianjin, 300071, China. dshguo@nankai.edu.cn.
Tianwei SunSchool of Medicine, Nankai University, Tianjin, China. billsuntw@163.com.

Funding

Hebei Administration of Traditional Chinese Medicine Science and Technology Project T2025020Tianjin Key Medical Discipline (Specialty) Construction Project TJYXZDXK-064BTianjin Municipal Science and Technology Project 22JCZDJC00250Tianjin Municipal Science and Technology Project 23JCZDJC01000
6 · The paper itself

Abstract

Current clinical management of fractures relies largely on surgical intervention and systemic pharmacotherapy, both of which are frequently associated with side effects and largely neglect early microenvironmental abnormalities. Precise elimination of senescent cells at the early stage may offer a more efficient means of restoring microenvironmental homeostasis and resetting regenerative dynamics. To this end, we designed and synthesized a multifunctional supramolecular nanoplatform, Asp

Indexed as

Cellular SenescenceFracture HealingSenotherapeuticsAnimalsDasatinibDrug Delivery SystemsHumansMiceOsteogenesisQuercetinDasatinibQuercetinSenotherapeuticsCombination therapyFracture healingSelf-assemblySenescenceSupramolecular materials

Identifiers

PMID41709294
PMCPMC13020410

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.