Evidence map›Paper›PMID 41709283›Full record

ArticlePerioperative medicine (London, England)2026

RAPID-CHD pathway improves clinical outcomes in neonates with congenital heart disease.

Chenyu Li, Zhongyuan Lu, Shilin Wang, Xia Li, Xiaofeng Wang, Qinnan Chen, Xu Wang

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In one paragraph

Article in Perioperative medicine (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chenyu Li *Pediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
Zhongyuan Lu *Pediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
Shilin WangPediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
Xia LiPediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
Xiaofeng WangPediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
Qinnan ChenPediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China.
Xu WangPediatric Intensive Care Unit, National Center for Cardiovascular Diseases and Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, No.167 North Lishi Road, Xicheng District, Beijing, 100037, China. fwpicu@163.com.

Funding

the Clinical Research Foundation of the National Health Commission of the People's Republic of China 2025-GSP-GG-19
6 · The paper itself

Abstract

backgroundTimely and effective management is crucial for neonates with critical congenital heart disease (CCHD). This study investigated the impact of the RAPID-CHD Pathway, a coordinated referral and transport system, compared with conventional management models.

methodsThis retrospective study included neonates (≤ 28 days) with CCHD admitted between January 2019 and December 2024. Group 1 comprised neonates enrolled in the RAPID-CHD Pathway: prenatally diagnosed, delivered in designated maternity hospitals, and transferred via a dedicated fast-track pathway. Group 2 included those referred from other hospitals or self-admitted. Major adverse events (MAEs) were defined as in-hospital death or discharge against medical advice. Logistic regression was used to assess associations between management strategies and MAEs.

resultsAmong 587 neonates (Group 1: n = 141; Group 2: n = 446), 439 underwent surgery (Group 1: n = 116; Group 2: n = 323). Group 1 had earlier ICU admission (0 vs 6 days, P < 0.001), earlier surgery (7 vs 15 days, P < 0.001), lower rates of low birth weight (< 2.5 kg: 5.7% vs 18.2%, P < 0.001), fewer emergency surgeries (9.5% vs 18.9%, P = 0.028), and higher surgical rates (82.3% vs 72.4%, P = 0.025). MAEs were lower in Group 1 (5.7% vs 12.6%, P = 0.033). Among patients who underwent surgery, the RAPID-CHD pathway remained associated with a trend toward reduced MAEs after adjustment (aOR 0.36; 95% CI, 0.11-1.20).

conclusionsThe RAPID-CHD Pathway improves early access to care, surgical opportunities, and outcomes in neonates with CCHD. It supports wider adoption in tertiary pediatric cardiac centers.

Indexed as

Cardiac surgeryCritical congenital heart diseaseIntegrated treatment modelMajor adverse eventsNeonates

Identifiers

PMID41709283
PMCPMC13019993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.