ArticleBMC urology2026
Investigation of the hematological parameters in women with Interstitial Cystitis/Bladder Pain Syndrome and their relationship with disease severity.
Article in BMC urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveInterstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is an important public health problem that mainly affects middle-aged female patients. Diagnosis of IC/BPS is difficult as there is no disease-specific diagnostic test. Our study evaluated routine hematological parameters in female IC/BPS patients to determine their potential utility in supporting diagnosis and reflecting disease severity.
methodsFifty female IC/BPS patients and 50 age-matched healthy controls were compared regarding neutrophil, lymphocyte, platelet counts, mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR). In the patient group, correlations between these parameters and O’Leary-Sant Interstitial Cystitis Symptom Index (ICSI) scores were analyzed.
resultsNeutrophil, lymphocyte, platelet counts, and MPV values were similar between groups, whereas NLR was significantly higher in IC/BPS patients (2.34 vs. 1.85, p < 0.001). Among patients, lymphocyte counts were higher in those with ICSI ≥ 14 compared with ICSI < 14 (1.90 vs. 1.62, p = 0.009).
conclusionElevated NLR may serve as an adjunctive marker supporting the diagnostic evaluation of IC/BPS, while lymphocyte count may be related to symptom severity. These routinely available parameters could offer additional clinical insight; however, their role should be confirmed in larger, prospective studies.
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