ReviewThyroid research2026
Safety and efficacy of peptide receptor radionuclide therapy for advanced medullary thyroid cancer: a systematic review and meta-analysis.
Review in Thyroid research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Molecular pathways and emerging therapeutic strategies in advanced thyroid cancer: from targeted therapy to precision oncology.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This systematic review and meta-analysis evaluated the safety and efficacy of somatostatin receptor (SSTR) peptide receptor radionuclide therapy (PRRT) in patients with metastatic or progressive medullary thyroid cancer (MTC). PubMed, Scopus, and Web of Science databases were systematically searched from inception to April 22, 2025, to identify relevant clinical studies. Methodological quality was assessed via the National Institutes of Health Quality Assessment Tool. Pooled estimates of the disease control rate (DCR), overall response rate (ORR), and adverse events (AEs) following SSTR PRRT administration were calculated for both the imaging and biochemical endpoints via Stata software version 17. The analysis revealed pooled DCRs of 52% (95% CI: 43–61%) and 58% (95% CI: 46–70%) for the biochemical and imaging endpoints, respectively. The pooled ORRs were 32% (95% CI: 23–42%) for the biochemical endpoints and 17% (95% CI: 7–26%) for the imaging endpoints. Compared with [90Y]Y-DOTATOC, [177Lu]Lu-DOTATATE had a slightly greater pooled imaging DCR (64% vs. 50%) and a lower overall toxicity rate (7% vs. 24%). The biochemical DCRs were comparable (51–52%), although [177Lu]Lu-DOTATATE achieved a higher biochemical ORR (37% vs. 29%). The [90Y]Y-DOTATOC group reported relatively higher rates of gastrointestinal and hematologic toxicities, with only limited cases of high-grade events reported in three studies. [177Lu]Lu-DOTATATE showed no renal toxicity, unlike [90Y]Y-DOTATOC, which mainly caused low-grade nephrotoxicity events at a pooled rate of 6%. Overall, this meta-analysis suggests that SSTR PRRT is a promising therapeutic option for metastatic or progressive MTC, achieving reliable disease control with a favorable safety profile.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.