ArticleJournal of general internal medicine2026
Advanced Versus Invasive Breast Cancer Risk in a Screening Population: Implications for Risk-based Prevention and Screening Strategies.
Article in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Advances in Breast Cancer Diagnostics: From Screening to Precision Medicine.Diagnostics (Basel, Switzerland) · 2026Review
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
backgroundMost risk-based breast cancer prevention and screening strategies rely on estimated invasive breast cancer risk. A recently developed model from the Breast Cancer Surveillance Consortium (BCSC) identifies women at elevated advanced cancer risk (prognostic pathologic stage II or greater) despite undergoing regular mammography screening.
objectiveTo describe the characteristics of women identified for risk-based interventions based on advanced versus invasive breast cancer risk.
designCross-sectional study.
participantsWomen aged 40-74 years undergoing mammography screening in routine clinical practice at 165 radiology facilities participating in the BCSC. MAIN MEASURES: Established BCSC risk models were used to calculate cumulative 6-year advanced breast cancer risk and BCSC 5-year invasive breast cancer risk, stratified by age, race and ethnicity, breast density, and body mass index. KEY
resultsAmong 756,971 included women, the Spearman correlation between advanced and invasive cancer risk scores was 0.75. 31.9% of women had intermediate/high (≥ 0.38%) advanced cancer risk and 32.5% had intermediate/high (≥ 1.67%) invasive cancer risk. 21.1% had intermediate/high risk in both models and 22.1% had intermediate/high risk in only one model. Thirty-five percent of women with intermediate/high invasive cancer risk had low/average advanced cancer risk, and 16% of women with low/average invasive cancer risk had intermediate/high advanced cancer risk. Among women with intermediate/high advanced cancer risk, 17.5% were age 40-49, 25.7% were Black, 69.7% had dense breasts, and 81.1% were overweight/obese. Among women with intermediate/high invasive breast cancer risk, 5.2% were age 40-49, 11.9% were Black, 56.5% had dense breasts, and 70.6% were overweight/obese.
conclusionsThere are substantial differences in the characteristics of women identified as having elevated risk based on the advanced versus invasive breast cancer risk models. The advanced cancer risk model is important for identifying women who are young, Black, overweight/obese, or have dense breasts at intermediate/higher advanced cancer risk for consideration of risk-based interventions.
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