Evidence map›Paper›PMID 41709069›Full record

ArticleTransfusion2026

The impact of rapid infusers on the hemostatic potential of cryoprecipitate products.

Connor D Purvis, Samantha Redden, Andrew Jacobson, Yao-Wei Wang, Julie Campbell, Jessica Cardenas, Jan-Michael Van Gent, Bryan A Cotton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Connor D PurvisDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.ORCID https://orcid.org/0009-0005-5030-8446
Samantha ReddenDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.
Andrew JacobsonDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.
Yao-Wei WangDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.
Julie CampbellDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.
Jessica CardenasDepartment of Surgery, University of Colorado-Anschutz Medical Campus, Aurora, Colorado, USA.
Jan-Michael Van GentDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0002-4655-2527
Bryan A CottonDepartment of Surgery, The McGovern Medical School at The University of Texas Health Science Center, Houston, Texas, USA.ORCID https://orcid.org/0000-0003-4184-6742

Funding

Cerus Corporation AGT011786
6 · The paper itself

Abstract

backgroundIn cases of massive transfusion, intravenous access can be limited. Additionally, delivering different products through separate lines and infusion methods adds unnecessary steps. RBC, plasma, and whole blood (WB) are delivered via rapid infusers; cryoprecipitate (CRYO) is infused through separate access and is not approved with these devices. STUDY DESIGN AND

methodsWe examined the impact of different transfusion methods on hemostatic performance and factor activity using two available CRYO products. Ten bags of CRYO, ten bags pathogen-reduced CRYO (Intercept® Fibrinogen Complex, IFC), and 20 units of WB were obtained. Each CRYO bag was infused with one unit of WB by three techniques: (1) gravity infusion with filter, (2) rapid infuser at 70 mL/min, and (3) pressure bag and filter. Hemostatic potential was measured by thrombelastography (TEG), thrombin generation (CAT), and factor levels (ACLTOP). Post-each infusion, disposable tubing and infusion parts were inspected for evidence of clumping or clogging.

resultsBoth standard CRYO and IFC demonstrated maintained or improved TEG, CAT, and factor levels when subjected to a rapid infuser device and pressure bag. When compared with gravity infusion, a rapid infuser device and pressure bag demonstrated maintained or improved values by TEG, CAT, and factor activity. No evidence of clumping or clogging of tubing was encountered in the 20 runs performed. No evidence of system dysfunction with use of CRYO through these devices was found either. DISCUSSION: Restriction of CRYO infusion through rapid infuser devices or with pressure bags should be reconsidered. Future clinical trials are warranted.

Indexed as

Blood TransfusionFactor VIIIFibrinogenHemostasisHumansThrombelastographyThrombincryoprecipitate coagulumFactor VIIIFibrinogenThrombincoagulopathycryoprecipitaterapid infusertrauma

Identifiers

PMID41709069
PMCPMC13184421

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.